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> Protein (NX_O14836)
Protein (NX_O14836)
Protein
Gene SymbolTNFRSF13B to neXtProt (NX_O14836)
DescriptionTumor necrosis factor receptor superfamily member 13B
Chromosome17
Location17p11.2 (16832849 ~ 16875432) to Ensembl
Sequene Features : Isoforms 3, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of B cell proliferation
.cell surface receptor signaling pathway
.hematopoietic progenitor cell differentiation
.B cell homeostasis
.receptor activity .external side of plasma membrane
.integral component of plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 76 7
2014-09-19protein level
3 53 7
2014-05-27protein level
3 53 7
2014-02-25protein level
2 53 7
2013-12-09protein level
2 35 7
2013-11-01protein level
2 32 7
2013-09-12protein level
2 32 7
2013-08-17protein level
2 32 7
2013-07-15protein level
2 28 7
2013-06-11protein level
2 28 7
2013-02-12protein level
2 21 11
2012-12-20protein level
2 20 11
2012-10-30protein level
2 27 11
2012-10-07protein level
2 27 7
2012-08-24protein level
2 24 7
2012-07-28protein level
2 24 7
2012-06-08protein level
2 5 7
2012-05-07protein level
2 5 7
2012-04-10protein level
2 5 7
2012-01-13protein level
2 5 7
2011-12-20protein level
2 20 7
2011-11-11protein level
2 20 7
2011-08-23protein level
2 20 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14836-1
0 13 0 31794.9913
NX_O14836-2
0 10 0 26646.7176
NX_O14836-3
3 7 0 19852.2871
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-519160,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-519160,EBI-447677 MYD88  
  .cellular response to mechanical stimulus
.3'-UTR-mediated mRNA stabilization
.response to interleukin-1
  + 22 more...
.TIR domain binding
.identical protein binding
.death receptor binding
.endosome membrane
.plasma membrane
.cytosol
3 EBI-519160,EBI-519169 TNFSF13B  
  .immunoglobulin secretion
.positive regulation of T cell proliferation
.B cell costimulation
  + 8 more...
.receptor binding .perinuclear region of cytoplasm
.integral component of membrane
.plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
intestine8
lymph67
spleen93
thymus25
trachea19
Health State
TissuesTPM*
normal2
lymphoma41
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix11.7
bone marrow1.3
colon2.8
duodenum3.9
esophagus1.1
lymph node18
salivary gland1.9
small intestine5.2
spleen24.3
stomach6.5
urinary bladder6.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#240500, phenotype) Immunodeficiency, common variable, 2; CVID2OMIM
2(*604907, gene) Tumor necrosis factor receptor superfamily, member 13b; TNFRSF13BOMIM
3(#609529, phenotype) Immunoglobulin a deficiency 2; IGAD2OMIM


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