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> Protein (NX_O14874)
Protein (NX_O14874)
Protein
Gene SymbolBCKDK to neXtProt (NX_O14874)
Description[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
Chromosome16
Location16p11.2 (31117428 ~ 31124110) to Ensembl
Sequene Features : Isoforms 3, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.phosphorylation
.branched-chain amino acid catabolic process
.cellular amino acid catabolic process
.protein phosphorylation
.[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
.kinase activity
.ATP binding
.protein serine/threonine kinase activity
.mitochondrial alpha-ketoglutarate dehydrogenase complex
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 46 5
2014-09-19protein level
3 35 5
2014-05-27protein level
3 35 5
2014-02-25protein level
1 35 5
2013-12-09protein level
1 25 5
2013-11-01protein level
1 24 4
2013-09-12protein level
1 24 5
2013-08-17protein level
1 24 5
2013-07-15protein level
1 12 5
2013-06-11protein level
1 12 5
2013-02-12protein level
1 6 8
2012-12-20protein level
1 5 8
2012-10-30protein level
1 6 8
2012-10-07protein level
1 6 8
2012-08-24protein level
1 6 8
2012-07-28protein level
1 6 8
2012-06-08protein level
1 7 8
2012-05-07protein level
1 5 8
2012-04-10protein level
1 5 8
2012-01-13protein level
1 4 8
2011-12-20protein level
1 4 8
2011-11-11protein level
1 4 8
2011-08-23protein level
1 4 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14874-1
2 16 0 46331.0414
NX_O14874-2
0 16 0 37743.6632
NX_O14874-3
0 17 0 41063.3297
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1046765,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland182
ascites25
bladder66
blood65
bone97
bone marrow20
brain73
cervix144
connective tissue46
embryonic tissue70
esophagus49
eye95
heart78
intestine94
kidney85
larynx85
liver102
lung77
lymph67
lymph node100
mammary gland66
mouth30
muscle103
nerve128
ovary98
pancreas89
placenta113
prostate63
salivary gland246
skin104
spleen56
stomach41
testis174
thymus75
thyroid193
umbilical cord72
uterus94
vascular38
Health State
TissuesTPM*
normal82
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma60
colorectal tumor35
esophageal tumor57
gastrointestinal tumor42
germ cell tumor49
glioma149
head and neck tumor119
kidney tumor72
leukemia31
liver tumor124
lung tumor97
lymphoma249
non-neoplasia93
ovarian tumor65
pancreatic tumor171
primitive neuroectodermal tumor of the CNS188
prostate cancer67
retinoblastoma64
skin tumor151
soft tissue/muscle tissue tumor63
uterine tumor122
Developmental Stage
TissuesTPM*
adult84
embryoid body71
blastocyst65
neonate64
fetus71
infant127
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.8
adrenal gland22.5
appendix18.5
bone marrow10
cerebral cortex15.7
colon15.8
duodenum15.2
esophagus18.6
gallbladder19.9
heart muscle29.9
kidney22.2
liver24.6
lung15
lymph node15.8
ovary17.9
pancreas26.4
placenta15.5
prostate19.9
salivary gland34.6
skin22.1
small intestine14.3
spleen18
stomach19.9
testis12.4
thyroid gland15.5
urinary bladder20.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaLow
pancreasHigh
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Low
small intestineHigh
soft tissue 2Low
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614901, gene) Branched-chain alpha-keto acid dehydrogenase kinase; BCKDKOMIM
2(#614923, phenotype) Branched-chain ketoacid dehydrogenase kinase deficiency; BCKDKDOMIM


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