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> Protein (NX_O14896)
Protein (NX_O14896)
Protein
Gene SymbolIRF6 to neXtProt (NX_O14896)
DescriptionInterferon regulatory factor 6
Chromosome1
Location1q32.2 (209959036 ~ 209979465) to Ensembl
Sequene Features : Isoforms 2, Variants 124, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mammary gland epithelial cell differentiation
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.regulatory region DNA binding
.extracellular exosome
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 124 3
2014-09-19protein level
2 99 3
2014-05-27protein level
2 99 3
2014-02-25protein level
2 98 3
2013-12-09protein level
2 88 3
2013-11-01protein level
2 86 3
2013-09-12protein level
2 86 3
2013-08-17protein level
2 86 3
2013-07-15protein level
2 67 3
2013-06-11protein level
2 67 3
2013-02-12protein level
1 55 2
2012-12-20protein level
1 57 2
2012-10-30protein level
1 60 2
2012-10-07protein level
1 60 2
2012-08-24protein level
1 52 2
2012-07-28protein level
1 52 2
2012-06-08protein level
1 52 2
2012-05-07protein level
1 51 2
2012-04-10protein level
1 51 2
2012-01-13protein level
1 50 2
2011-12-20protein level
1 50 2
2011-11-11protein level
1 50 2
2011-08-23protein level
1 50 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14896-1
5 17 0 53095.4642
NX_O14896-2
0 17 0 41902.6697
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6115643,EBI-2866563 IRF8  
  .cellular response to lipopolysaccharide
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
  + 12 more...
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
.regulatory region DNA binding
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder133
bone marrow61
brain18
cervix20
connective tissue6
embryonic tissue51
esophagus248
eye28
heart89
intestine133
kidney33
larynx170
liver38
lung32
lymph node11
mammary gland79
mouth241
muscle47
nerve64
ovary49
pancreas18
pharynx245
pituitary gland60
placenta84
prostate63
skin66
stomach20
testis13
thymus62
thyroid107
trachea386
uterus107
Health State
TissuesTPM*
normal39
bladder carcinoma170
breast (mammary gland) tumor85
cervical tumor28
chondrosarcoma12
colorectal tumor195
esophageal tumor289
gastrointestinal tumor33
germ cell tumor11
glioma9
head and neck tumor239
kidney tumor14
leukemia21
liver tumor31
lung tumor58
lymphoma13
non-neoplasia41
ovarian tumor39
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
retinoblastoma21
skin tumor39
uterine tumor122
Developmental Stage
TissuesTPM*
adult68
embryoid body100
neonate32
fetus28
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.2
adrenal gland8.2
appendix3.8
bone marrow1.8
colon30.9
duodenum27.2
esophagus60.3
gallbladder13
heart muscle26.7
kidney17.3
liver16.4
lung10.3
lymph node1.1
ovary2.1
pancreas11.4
placenta26.1
prostate30.6
salivary gland22.3
skin63.3
small intestine26.3
spleen2.3
stomach25.7
testis4.2
thyroid gland17.2
urinary bladder30.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#119300, phenotype) Van der woude syndrome 1; VWS1OMIM
2(#119500, phenotype) Popliteal pterygium syndrome; PPSOMIM
3(*607199, gene) Interferon regulatory factor 6; IRF6OMIM
4(#608864, phenotype) Orofacial cleft 6, susceptibility to; OFC6OMIM


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