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> Protein (NX_O14908)
Protein (NX_O14908)
Protein
Gene SymbolGIPC1 to neXtProt (NX_O14908)
DescriptionPDZ domain-containing protein GIPC1
Chromosome19
Location19p13.12 (14588572 ~ 14606944) to Ensembl
Sequene Features : Isoforms 2, Variants 31, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of synaptic plasticity
.endothelial cell migration
.positive regulation of cytokinesis
  + 7 more...
.protein homodimerization activity
.myosin binding
.receptor binding
.actin binding
.extracellular exosome
.dendritic shaft
.dendritic spine
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 31 6
2014-09-19protein level
2 23 6
2014-05-27protein level
2 23 6
2014-02-25protein level
2 23 5
2013-12-09protein level
2 18 5
2013-11-01protein level
2 17 5
2013-09-12protein level
2 17 5
2013-08-17protein level
2 17 5
2013-07-15protein level
2 12 3
2013-06-11protein level
2 12 3
2013-02-12protein level
2 6 4
2012-12-20protein level
2 7 4
2012-10-30protein level
2 7 4
2012-10-07protein level
2 7 2
2012-08-24protein level
1 6 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 6 2
2012-05-07protein level
1 6 2
2012-04-10protein level
1 6 2
2012-01-13protein level
1 10 2
2011-12-20protein level
1 10 2
2011-11-11protein level
1 10 1
2011-08-23protein level
1 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14908-1
5 9 1 36026.5862
NX_O14908-2
1 9 1 26055.3254
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-373132,EBI-7900408 TYRP1  
  .positive regulation of melanin biosynthetic process
.acetoacetic acid metabolic process
.melanin biosynthetic process
  + 2 more...
.protein heterodimerization activity
.protein homodimerization activity
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
.copper ion binding
.melanosome
.melanosome membrane
.clathrin-coated endocytic vesicle membrane
  + 2 more...
2 EBI-373132,EBI-2852679 TGFBR3  
  .pathway-restricted SMAD protein phosphorylation
.heart trabecula formation
.definitive erythrocyte differentiation
  + 30 more...
.transforming growth factor beta receptor activity, type III
.transforming growth factor beta binding
.SMAD binding
  + 7 more...
.extracellular exosome
.receptor complex
.inhibin-betaglycan-ActRII complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites75
bladder133
bone83
bone marrow20
brain27
cervix103
connective tissue13
embryonic tissue37
eye119
heart44
intestine90
kidney80
liver53
lung65
lymph67
mammary gland92
muscle65
ovary108
pancreas154
placenta67
prostate94
salivary gland148
skin189
spleen56
stomach52
testis18
thymus25
tonsil117
trachea19
uterus142
vascular38
Health State
TissuesTPM*
normal15
bladder carcinoma284
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma60
colorectal tumor8
gastrointestinal tumor42
germ cell tumor15
glioma46
head and neck tumor22
kidney tumor43
leukemia31
liver tumor10
lung tumor58
lymphoma41
non-neoplasia31
ovarian tumor13
pancreatic tumor66
primitive neuroectodermal tumor of the CNS118
prostate cancer96
retinoblastoma43
skin tumor303
soft tissue/muscle tissue tumor159
uterine tumor199
Developmental Stage
TissuesTPM*
adult15
embryoid body85
blastocyst81
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25
adrenal gland17.9
appendix16
bone marrow1.9
cerebral cortex25.3
colon65.4
duodenum19.2
esophagus61.5
gallbladder20.7
heart muscle19.1
kidney32.3
liver9.8
lung35.5
lymph node12.5
ovary10.7
pancreas10.9
placenta27.6
prostate28.2
salivary gland24
skin49.4
small intestine18.8
spleen20.3
stomach52.8
testis13.2
thyroid gland18.3
urinary bladder24
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605072, gene) Gipc pdz domain-containing family, member 1; GIPC1OMIM


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