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> Protein (NX_O14939)
Protein (NX_O14939)
Protein
Gene SymbolPLD2 to neXtProt (NX_O14939)
DescriptionPhospholipase D2
Chromosome17
Location17p13.2 (4710391 ~ 4726729) to Ensembl
Sequene Features : Isoforms 3, Variants 138, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of phagocytosis
.inositol lipid-mediated signaling
.glycerophospholipid biosynthetic process
  + 12 more...
.N-acylphosphatidylethanolamine-specific phospholipase D activity
.phosphatidylinositol binding
.phospholipase D activity
.brush border membrane
.plasma membrane
.endoplasmic reticulum membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 138 0
2014-09-19protein level
3 111 0
2014-05-27protein level
3 111 0
2014-02-25protein level
3 111 0
2013-12-09protein level
3 75 0
2013-11-01protein level
3 70 0
2013-09-12protein level
3 70 0
2013-08-17protein level
3 70 0
2013-07-15protein level
3 55 0
2013-06-11protein level
3 55 0
2013-02-12protein level
3 37 0
2012-12-20protein level
3 35 0
2012-10-30protein level
3 44 0
2012-10-07protein level
3 44 0
2012-08-24protein level
3 41 0
2012-07-28protein level
3 41 0
2012-06-08protein level
3 48 0
2012-05-07protein level
3 48 0
2012-04-10protein level
3 48 0
2012-01-13protein level
3 27 0
2011-12-20protein level
3 27 0
2011-11-11protein level
3 27 0
2011-08-23protein level
3 27 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14939-1
2 44 0 105919.9328
NX_O14939-3
0 16 0 38227.3107
NX_O14939-4
1 44 0 104591.208
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053996,EBI-352733 CFL1  
  .regulation of dendritic spine morphogenesis
.ephrin receptor signaling pathway
.negative regulation of cell size
  + 21 more...
.N/A .extracellular exosome
.ruffle membrane
.vesicle
  + 9 more...
2 EBI-1053996,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites50
blood8
bone97
brain43
connective tissue26
embryonic tissue37
esophagus49
eye14
heart11
intestine30
kidney37
liver4
lung44
lymph node11
mammary gland33
mouth272
muscle28
ovary49
pancreas56
pituitary gland60
placenta56
prostate42
salivary gland49
skin18
spleen18
stomach20
testis25
thymus87
thyroid42
trachea77
umbilical cord799
uterus43
vascular19
Health State
TissuesTPM*
normal36
bladder carcinoma113
breast (mammary gland) tumor32
chondrosarcoma72
colorectal tumor26
esophageal tumor57
gastrointestinal tumor42
germ cell tumor49
glioma74
head and neck tumor127
kidney tumor58
leukemia10
liver tumor10
lung tumor19
non-neoplasia20
ovarian tumor52
pancreatic tumor95
primitive neuroectodermal tumor of the CNS23
prostate cancer67
skin tumor31
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult37
embryoid body28
blastocyst65
neonate64
fetus50
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.3
adrenal gland8.8
appendix20.2
bone marrow3.7
cerebral cortex14.8
colon10.7
duodenum10.6
esophagus38.1
gallbladder20.5
heart muscle8.6
kidney7.3
liver7.5
lung18.5
lymph node15.1
ovary22.6
pancreas4
placenta17.7
prostate16.5
salivary gland13.1
skin44.2
small intestine10.2
spleen16.9
stomach14.1
testis6.7
thyroid gland9.8
urinary bladder16.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumLow
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverHigh
lungMedium
nasopharynxHigh
oral mucosaLow
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skin 1Medium
skin 2Low
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
stomach 1Low
stomach 2High
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602384, gene) Phospholipase d2; PLD2OMIM


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