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> Protein (NX_O14964)
Protein (NX_O14964)
Protein
Gene SymbolHGS to neXtProt (NX_O14964)
DescriptionHepatocyte growth factor-regulated tyrosine kinase substrate
Chromosome17
Location17q25.3 (79650356 ~ 79670168) to Ensembl
Sequene Features : Isoforms 2, Variants 81, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 81 19
2014-09-19protein level
2 62 19
2014-05-27protein level
2 62 19
2014-02-25protein level
2 61 18
2013-12-09protein level
2 44 18
2013-11-01protein level
2 44 10
2013-09-12protein level
2 44 10
2013-08-17protein level
2 44 10
2013-07-15protein level
2 22 7
2013-06-11protein level
2 22 7
2013-02-12protein level
2 11 20
2012-12-20protein level
2 10 20
2012-10-30protein level
2 13 20
2012-10-07protein level
2 13 10
2012-08-24protein level
2 13 10
2012-07-28protein level
2 13 10
2012-06-08protein level
2 16 10
2012-05-07protein level
2 16 10
2012-04-10protein level
2 16 10
2012-01-13protein level
2 9 10
2011-12-20protein level
2 9 10
2011-11-11protein level
2 9 10
2011-08-23protein level
2 9 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14964-1
2 19 0 86137.303
NX_O14964-2
1 19 0 76327.3617
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740220,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-740220,EBI-373498 MIF4GD  
  .regulation of translation .protein C-terminus binding
.RNA binding
.cytoplasm
.nucleolus
3 EBI-740220,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
4 EBI-740220,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
5 EBI-740220,EBI-1050106 BCAS2  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .cell junction
.nucleolus
.spliceosomal complex
  + 2 more...
6 EBI-740220,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
7 EBI-740220,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
8 EBI-740220,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
9 EBI-740220,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
10 EBI-740220,EBI-711360 CSTF2  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.cleavage body
.mRNA cleavage and polyadenylation specificity factor complex
.nucleoplasm
.nucleus
11 EBI-740220,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
12 EBI-740220,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
13 EBI-740220,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
14 EBI-740220,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
15 EBI-740220,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-740220,EBI-741048 NUP54  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.cytoplasm
.nucleoplasm
  + 2 more...
17 EBI-740220,EBI-1389308 POGZ  
  .kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
18 EBI-740220,EBI-10181968 P4HA3  
  .N/A .L-ascorbic acid binding
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
.iron ion binding
.procollagen-proline 4-dioxygenase activity
.endoplasmic reticulum lumen
19 EBI-740220,EBI-10261970 CCDC103  
  .determination of digestive tract left/right asymmetry
.axonemal dynein complex assembly
.epithelial cilium movement involved in determination of left/right asymmetry
  + 5 more...
.protein homodimerization activity .motile cilium
.axoneme
.cytoplasm
20 EBI-740220,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
21 EBI-740220,EBI-741424 MAPK1IP1L  
  .N/A .N/A .N/A
22 EBI-740220,EBI-488533 ING5  
  .positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
23 EBI-740220,EBI-752007 JAKMIP2  
  .N/A .N/A .Golgi apparatus
24 EBI-740220,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
25 EBI-740220,EBI-5663129 INTS4  
  .snRNA processing .N/A .integrator complex
26 EBI-740220,EBI-10173858 CCDC114  
  .outer dynein arm assembly .N/A .outer dynein arm
.cilium
27 EBI-740220,EBI-725647 LITAF  
  .cellular response to lipopolysaccharide
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of NF-kappaB import into nucleus
  + 6 more...
.WW domain binding
.signal transducer activity
.intracellular membrane-bounded organelle
.plasma membrane
.Golgi apparatus
  + 3 more...
28 EBI-740220,EBI-747012 CSTF2T  
  .mRNA processing .poly(A) RNA binding
.nucleotide binding
.nucleus
.intracellular
29 EBI-740220,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
30 EBI-740220,EBI-1774273 CTTNBP2NL  
  .negative regulation of transmembrane transport
.negative regulation of transporter activity
.protein dephosphorylation
.protein phosphatase 2A binding .actin cytoskeleton
.cytoplasm
31 EBI-740220,EBI-724639 PEF1  
  .response to calcium ion
.proteolysis
.protein dimerization activity
.protein heterodimerization activity
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.membrane
.cytoplasm
32 EBI-740220,EBI-751422 SNX7  
  .vesicle organization
.protein transport
.endocytosis
.phosphatidylinositol binding .cytoplasmic vesicle membrane
.extrinsic component of membrane
.endosome
33 EBI-740220,EBI-720048 EXOC7  
  .membrane organization
.cellular protein metabolic process
.protein transport
  + 2 more...
.N/A .centriolar satellite
.growth cone membrane
.membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder100
blood89
bone111
brain48
cervix103
connective tissue40
embryonic tissue89
eye86
heart33
intestine94
kidney56
larynx340
liver34
lung74
lymph22
lymph node55
mammary gland72
mouth120
muscle84
nerve193
ovary88
pancreas107
pituitary gland121
placenta77
prostate26
salivary gland49
skin246
spleen93
stomach52
testis87
thymus12
thyroid42
tonsil117
trachea19
umbilical cord145
uterus90
Health State
TissuesTPM*
normal45
bladder carcinoma284
breast (mammary gland) tumor107
cervical tumor86
chondrosarcoma132
colorectal tumor133
gastrointestinal tumor59
germ cell tumor87
glioma167
head and neck tumor149
kidney tumor130
leukemia137
liver tumor62
lung tumor97
lymphoma69
non-neoplasia31
ovarian tumor26
pancreatic tumor161
primitive neuroectodermal tumor of the CNS228
prostate cancer28
retinoblastoma107
skin tumor374
soft tissue/muscle tissue tumor127
uterine tumor166
Developmental Stage
TissuesTPM*
adult70
embryoid body71
blastocyst97
neonate64
fetus28
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.9
adrenal gland34.7
appendix37.6
bone marrow69.2
cerebral cortex42.1
colon31.3
duodenum35.3
esophagus37.1
gallbladder30
heart muscle22.6
kidney20.8
liver13.6
lung39
lymph node36.3
ovary39.2
pancreas16.4
placenta34
prostate29.3
salivary gland33.9
skin63.5
small intestine34.2
spleen46.8
stomach37.4
testis42.8
thyroid gland30.5
urinary bladder28.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisLow
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
lungLow
nasopharynxLow
oral mucosaLow
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 2Low
small intestineMedium
smooth muscleLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604375, gene) Human growth factor-regulated tyrosine kinase substrate; HGSOMIM


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