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> Protein (NX_O14965)
Protein (NX_O14965)
Protein
Gene SymbolAURKA to neXtProt (NX_O14965)
DescriptionAurora kinase A
Chromosome20
Location20q13.2 (54944445 ~ 54967393) to Ensembl
Sequene Features : Isoforms 1, Variants 42, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neuron projection extension
.positive regulation of oocyte maturation
.negative regulation of spindle checkpoint
  + 21 more...
.histone serine kinase activity
.protein kinase binding
.ATP binding
  + 3 more...
.meiotic spindle
.mitotic spindle
.spindle midzone
  + 14 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 42 5
2014-09-19protein level
1 32 5
2014-05-27protein level
1 32 6
2014-02-25protein level
1 32 6
2013-12-09protein level
1 28 6
2013-11-01protein level
1 26 6
2013-09-12protein level
1 26 6
2013-08-17protein level
1 26 6
2013-07-15protein level
1 22 5
2013-06-11protein level
1 22 5
2013-02-12protein level
1 15 8
2012-12-20protein level
1 15 8
2012-10-30protein level
1 17 8
2012-10-07protein level
1 17 8
2012-08-24protein level
1 10 8
2012-07-28protein level
1 10 8
2012-06-08protein level
1 19 8
2012-05-07protein level
1 19 8
2012-04-10protein level
1 19 8
2012-01-13protein level
1 25 8
2011-12-20protein level
1 26 8
2011-11-11protein level
1 26 8
2011-08-23protein level
1 23 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14965-1
20 0 1 45780.7099
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-448680,EBI-389606 TP73  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.negative regulation of cardiac muscle cell proliferation
.protein tetramerization
  + 31 more...
.metal ion binding
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.intracellular membrane-bounded organelle
.cell junction
.cytosol
  + 5 more...
2 EBI-448680,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-448680,EBI-878369 MYCN  
  .negative regulation of reactive oxygen species metabolic process
.branching morphogenesis of an epithelial tube
.negative regulation of astrocyte differentiation
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
.chromatin
4 EBI-448680,EBI-78579 NPM1  
  .regulation of eIF2 alpha phosphorylation by dsRNA
.regulation of endoribonuclease activity
.protein oligomerization
  + 20 more...
.unfolded protein binding
.NF-kappaB binding
.protein heterodimerization activity
  + 10 more...
.spindle pole centrosome
.ribonucleoprotein complex
.membrane
  + 7 more...
5 EBI-448680,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
6 EBI-448680,EBI-713456 IK  
  .cell-cell signaling
.immune response
.identical protein binding .nucleolus
.nucleoplasm
.extracellular space
7 EBI-448680,EBI-448665 AURKAIP1  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 4 more...
.N/A .intracellular membrane-bounded organelle
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
8 EBI-448680,EBI-1037322 TPX2  
  .regulation of mitotic spindle organization
.cell division
.activation of protein kinase activity
  + 3 more...
.protein kinase binding
.GTP binding
.ATP binding
.axon hillock
.microtubule cytoskeleton
.microtubule
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites150
bladder66
blood57
bone195
bone marrow41
brain19
cervix206
connective tissue33
embryonic tissue93
esophagus297
eye19
heart22
intestine73
kidney52
liver116
lung26
lymph45
lymph node89
mammary gland59
muscle94
ovary39
pancreas18
pharynx73
placenta35
prostate73
skin61
spleen18
testis165
thymus25
thyroid21
tonsil58
umbilical cord72
uterus34
vascular38
Health State
TissuesTPM*
normal41
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor144
chondrosarcoma84
colorectal tumor88
esophageal tumor347
gastrointestinal tumor75
germ cell tumor140
glioma55
head and neck tumor7
kidney tumor58
leukemia21
liver tumor156
lung tumor48
lymphoma96
non-neoplasia10
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS165
prostate cancer125
retinoblastoma86
skin tumor87
soft tissue/muscle tissue tumor95
uterine tumor22
Developmental Stage
TissuesTPM*
adult39
embryoid body28
blastocyst48
neonate128
fetus53
infant212
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.2
adrenal gland1.4
appendix10.2
bone marrow9.3
cerebral cortex1.2
colon10.1
duodenum10.7
esophagus5.3
gallbladder1.9
heart muscle4.3
kidney1.8
liver2.1
lung1.8
lymph node18.4
ovary1.3
pancreas1.2
placenta8.5
prostate1.1
skin2.6
small intestine8.1
spleen3.5
stomach5.2
testis28.1
thyroid gland1.4
urinary bladder5.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603072, gene) Aurora kinase a; AURKAOMIM


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