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> Protein (NX_O14974)
Protein (NX_O14974)
Protein
Gene SymbolPPP1R12A to neXtProt (NX_O14974)
DescriptionProtein phosphatase 1 regulatory subunit 12A
Chromosome12
Location12q21.2 (80167343 ~ 80329240) to Ensembl
Sequene Features : Isoforms 5, Variants 88, PTMs 29 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.centrosome organization
.regulation of nucleocytoplasmic transport
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.14-3-3 protein binding
.protein kinase binding
.phosphatase regulator activity
  + 2 more...
.PTW/PP1 phosphatase complex
.contractile fiber
.actin cytoskeleton
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 88 29
2014-09-19protein level
5 72 30
2014-05-27protein level
5 72 30
2014-02-25protein level
5 73 30
2013-12-09protein level
5 56 30
2013-11-01protein level
5 56 29
2013-09-12protein level
5 56 29
2013-08-17protein level
5 56 29
2013-07-15protein level
5 34 33
2013-06-11protein level
5 34 33
2013-02-12protein level
5 15 149
2012-12-20protein level
4 14 121
2012-10-30protein level
4 20 121
2012-10-07protein level
4 20 31
2012-08-24protein level
4 12 31
2012-07-28protein level
4 12 31
2012-06-08protein level
4 28 31
2012-05-07protein level
4 28 31
2012-04-10protein level
4 28 31
2012-01-13protein level
4 29 28
2011-12-20protein level
4 29 28
2011-11-11protein level
4 28 29
2011-08-23protein level
4 25 27
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14974-1
0 39 2 115210.9802
NX_O14974-2
0 37 2 111117.8514
NX_O14974-3
0 36 2 109661.2682
NX_O14974-4
1 36 2 109037.8617
NX_O14974-5
0 36 2 105577.1421
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351726,EBI-77293 DAPK3  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 23 more...
.leucine zipper domain binding
.protein homodimerization activity
.identical protein binding
  + 5 more...
.membrane raft
.PML body
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites75
bladder200
blood139
bone111
bone marrow41
brain71
connective tissue53
ear248
embryonic tissue103
esophagus99
eye119
heart55
intestine137
kidney80
larynx42
liver53
lung110
lymph node111
mammary gland132
mouth45
muscle131
nerve193
ovary19
pancreas103
parathyroid97
pharynx73
placenta95
prostate94
salivary gland49
skin42
spleen18
stomach135
testis66
thymus163
thyroid42
tonsil58
trachea57
umbilical cord217
uterus133
vascular232
Health State
TissuesTPM*
normal99
breast (mammary gland) tumor118
chondrosarcoma72
colorectal tumor151
esophageal tumor115
gastrointestinal tumor75
germ cell tumor151
glioma65
head and neck tumor44
kidney tumor58
leukemia116
liver tumor83
lung tumor9
non-neoplasia31
ovarian tumor39
pancreatic tumor152
primitive neuroectodermal tumor of the CNS31
prostate cancer38
skin tumor15
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult95
embryoid body157
blastocyst32
neonate160
fetus111
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30
adrenal gland23.8
appendix46.9
bone marrow48.8
cerebral cortex28.8
colon32.5
duodenum23.3
esophagus70.4
gallbladder43.9
heart muscle22.3
kidney20.9
liver12.1
lung28.1
lymph node36.7
ovary29.8
pancreas6.3
placenta38.5
prostate65.9
salivary gland17.1
skin18.2
small intestine29.3
spleen32.9
stomach20.9
testis30.4
thyroid gland30.1
urinary bladder64.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602021, gene) Protein phosphatase 1, regulatory subunit 12a; PPP1R12AOMIM


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