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> Protein (NX_O14976)
Protein (NX_O14976)
Protein
Gene SymbolGAK to neXtProt (NX_O14976)
DescriptionCyclin-G-associated kinase
Chromosome4
Location4p16.3 (843064 ~ 926161) to Ensembl
Sequene Features : Isoforms 2, Variants 177, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of neural precursor cell proliferation
.clathrin-mediated endocytosis
.clathrin coat disassembly
  + 8 more...
.ATP binding
.protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 177 15
2014-09-19protein level
2 146 15
2014-05-27protein level
2 146 15
2014-02-25protein level
1 146 15
2013-12-09protein level
1 97 15
2013-11-01protein level
1 92 15
2013-09-12protein level
1 92 15
2013-08-17protein level
1 92 15
2013-07-15protein level
1 69 14
2013-06-11protein level
1 69 14
2013-02-12protein level
1 45 24
2012-12-20protein level
1 45 24
2012-10-30protein level
1 48 24
2012-10-07protein level
1 48 24
2012-08-24protein level
1 39 24
2012-07-28protein level
1 39 24
2012-06-08protein level
1 40 24
2012-05-07protein level
1 40 24
2012-04-10protein level
1 40 24
2012-01-13protein level
1 25 24
2011-12-20protein level
1 25 24
2011-11-11protein level
1 25 24
2011-08-23protein level
1 25 24
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O14976-1
6 56 0 143099.8573
NX_O14976-2
1 56 0 134378.5373
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714707,EBI-351896 HSPA8  
  .negative regulation of fibril organization
.regulation of cellular response to heat
.clathrin coat disassembly
  + 18 more...
.C3HC4-type RING finger domain binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.blood microparticle
.extracellular exosome
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
  + 13 more...
2 EBI-714707,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
3 EBI-714707,EBI-6308763 ATP13A2  
  .cellular response to manganese ion
.metabolic process
.cation transport
.metal ion binding
.ATPase activity
.ATP binding
.integral component of membrane
.lysosomal membrane
.lysosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites100
bladder66
blood98
bone55
brain75
cervix41
connective tissue33
embryonic tissue65
eye43
heart22
intestine137
kidney61
liver19
lung74
lymph22
lymph node144
mammary gland66
mouth60
muscle37
nerve128
ovary137
pancreas46
parathyroid242
pituitary gland181
placenta81
prostate52
salivary gland296
skin42
spleen56
stomach41
testis98
thymus125
thyroid42
trachea115
uterus34
Health State
TissuesTPM*
normal58
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma60
colorectal tumor142
gastrointestinal tumor67
germ cell tumor56
glioma83
head and neck tumor82
kidney tumor87
leukemia116
lung tumor68
lymphoma41
non-neoplasia31
ovarian tumor131
pancreatic tumor85
primitive neuroectodermal tumor of the CNS55
prostate cancer57
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult70
embryoid body57
blastocyst97
fetus50
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.1
adrenal gland18.4
appendix29.5
bone marrow33.3
cerebral cortex19.3
colon36.2
duodenum50.1
esophagus22.1
gallbladder23.6
heart muscle7.8
kidney28.2
liver8.8
lung25.9
lymph node32.9
ovary15.9
pancreas17.8
placenta18.5
prostate24
salivary gland62.5
skin36.6
small intestine45.7
spleen44.7
stomach50.8
testis40.2
thyroid gland20.6
urinary bladder22.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602052, gene) Cyclin g-associated kinase; GAKOMIM


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