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> Protein (NX_O15031)
Protein (NX_O15031)
Protein
Gene SymbolPLXNB2 to neXtProt (NX_O15031)
DescriptionPlexin-B2
Chromosome22
Location22q13.33 (50713408 ~ 50746056) to Ensembl
Sequene Features : Isoforms 1, Variants 226, PTMs 27 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of neuron migration
.semaphorin-plexin signaling pathway
.positive regulation of axonogenesis
  + 6 more...
.semaphorin receptor activity .extracellular exosome
.cell surface
.integral component of plasma membrane
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 226 27
2014-09-19protein level
1 170 27
2014-05-27protein level
1 170 27
2014-02-25protein level
1 169 27
2013-12-09protein level
1 123 27
2013-11-01protein level
1 118 26
2013-09-12protein level
1 118 25
2013-08-17protein level
1 118 25
2013-07-15protein level
1 72 25
2013-06-11protein level
1 72 25
2013-02-12protein level
1 26 24
2012-12-20protein level
1 25 24
2012-10-30protein level
1 37 24
2012-10-07protein level
1 37 24
2012-08-24protein level
1 25 24
2012-07-28protein level
1 25 24
2012-06-08protein level
1 27 24
2012-05-07protein level
1 27 24
2012-04-10protein level
1 27 24
2012-01-13protein level
1 22 13
2011-12-20protein level
1 22 13
2011-11-11protein level
1 22 13
2011-08-23protein level
1 22 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15031-1
81 0 0 204996.5985
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-722004,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
2 EBI-722004,EBI-2637518 MST1R  
  .positive regulation of protein kinase B signaling
.innate immune response
.positive regulation of MAP kinase activity
  + 9 more...
.enzyme binding
.ATP binding
.macrophage colony-stimulating factor receptor activity
.cell surface
.integral component of plasma membrane
.stress fiber
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites75
bladder167
blood8
bone69
brain1
cervix144
connective tissue80
embryonic tissue18
esophagus148
eye148
heart55
intestine215
kidney156
larynx85
liver73
lung104
lymph22
lymph node267
mammary gland6
mouth151
muscle244
nerve450
ovary384
pancreas145
parathyroid97
pharynx147
pituitary gland121
placenta3
prostate153
salivary gland148
skin94
spleen74
stomach177
testis2
thymus25
thyroid236
trachea135
umbilical cord145
uterus137
vascular19
Health State
TissuesTPM*
normal2
bladder carcinoma170
breast (mammary gland) tumor182
cervical tumor57
chondrosarcoma181
colorectal tumor319
esophageal tumor115
gastrointestinal tumor194
germ cell tumor129
glioma74
head and neck tumor209
kidney tumor362
liver tumor104
lung tumor87
lymphoma13
non-neoplasia62
ovarian tumor223
pancreatic tumor276
primitive neuroectodermal tumor of the CNS55
prostate cancer163
retinoblastoma107
skin tumor111
soft tissue/muscle tissue tumor167
uterine tumor266
Developmental Stage
TissuesTPM*
adult1
embryoid body28
blastocyst16
neonate96
fetus1
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.6
adrenal gland44.5
appendix32.8
bone marrow13.2
cerebral cortex15.1
colon51
duodenum45.8
esophagus40.4
gallbladder71.8
heart muscle19.5
kidney77.8
liver38.5
lung59.2
lymph node33.3
ovary53.8
pancreas26.1
placenta45.5
prostate62.8
salivary gland51.7
skin61.5
small intestine47.7
spleen82
stomach85.5
testis31.2
thyroid gland54.2
urinary bladder52.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604293, gene) Plexin b2; PLXNB2OMIM


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