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> Protein (NX_O15047)
Protein (NX_O15047)
Protein
Gene SymbolSETD1A to neXtProt (NX_O15047)
DescriptionHistone-lysine N-methyltransferase SETD1A
Chromosome16
Location16p11.2 (30968615 ~ 30996437) to Ensembl
Sequene Features : Isoforms 1, Variants 212, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.stem cell maintenance
  + 3 more...
.histone methyltransferase activity (H3-K4 specific)
.RNA binding
.nucleotide binding
.Set1C/COMPASS complex
.histone methyltransferase complex
.nuclear speck
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 212 7
2014-09-19protein level
1 150 7
2014-05-27protein level
1 150 7
2014-02-25protein level
1 148 7
2013-12-09protein level
1 107 7
2013-11-01protein level
1 99 7
2013-09-12protein level
1 99 7
2013-08-17protein level
1 99 7
2013-07-15protein level
1 73 7
2013-06-11protein level
1 73 7
2013-02-12protein level
1 35 4
2012-12-20protein level
1 35 4
2012-10-30protein level
1 40 4
2012-10-07protein level
1 40 4
2012-08-24protein level
1 38 4
2012-07-28protein level
1 38 4
2012-06-08protein level
1 42 4
2012-05-07protein level
1 27 4
2012-04-10protein level
1 27 4
2012-01-13protein level
1 13 4
2011-12-20protein level
1 13 4
2011-11-11protein level
1 13 4
2011-08-23protein level
1 13 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15047-1
64 0 1 185919.6144
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-540779,EBI-396176 HCFC1  
  .protein stabilization
.positive regulation of cell cycle
.histone H4-K16 acetylation
  + 12 more...
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.MLL1 complex
.MLL5-L complex
.Set1C/COMPASS complex
  + 7 more...
2 EBI-540779,EBI-592823 RBBP5  
  .histone H3-K4 methylation
.response to estrogen
.cellular response to DNA damage stimulus
  + 3 more...
.transcription regulatory region DNA binding
.methylated histone binding
.MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone13
brain4
connective tissue6
embryonic tissue18
eye38
heart11
intestine43
kidney9
larynx42
lung23
lymph node111
mammary gland112
muscle9
nerve64
ovary59
pancreas18
placenta24
skin90
stomach20
testis22
tonsil117
uterus25
Health State
TissuesTPM*
normal20
bladder carcinoma113
breast (mammary gland) tumor150
chondrosarcoma36
colorectal tumor26
gastrointestinal tumor25
germ cell tumor22
glioma37
head and neck tumor7
kidney tumor14
leukemia21
lung tumor38
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
skin tumor95
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult27
embryoid body28
blastocyst32
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.2
adrenal gland5.2
appendix6.7
bone marrow11.2
cerebral cortex5.8
colon5
duodenum4.7
esophagus5.6
gallbladder5.5
heart muscle4.2
kidney4.8
liver2.4
lung6
lymph node7.7
ovary9.6
pancreas3.8
placenta5.8
prostate5.8
salivary gland4.9
skin5.8
small intestine5.1
spleen7.8
stomach5
testis17.3
thyroid gland7.8
urinary bladder5.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Low
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611052, gene) Set domain-containing protein 1a; SETD1AOMIM


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