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> Protein (NX_O15085)
Protein (NX_O15085)
Protein
Gene SymbolARHGEF11 to neXtProt (NX_O15085)
DescriptionRho guanine nucleotide exchange factor 11
Chromosome1
Location1q23.1 (156904632 ~ 157015162) to Ensembl
Sequene Features : Isoforms 2, Variants 196, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 14 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.G-protein coupled receptor binding
.membrane
.cytosol
.cytoplasm
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 196 24
2014-09-19protein level
2 149 24
2014-05-27protein level
2 148 24
2014-02-25protein level
2 149 24
2013-12-09protein level
2 117 24
2013-11-01protein level
2 110 24
2013-09-12protein level
2 110 24
2013-08-17protein level
2 110 24
2013-07-15protein level
2 80 24
2013-06-11protein level
2 80 24
2013-02-12protein level
2 40 36
2012-12-20protein level
2 41 36
2012-10-30protein level
2 47 36
2012-10-07protein level
2 47 18
2012-08-24protein level
2 26 18
2012-07-28protein level
2 26 18
2012-06-08protein level
2 26 18
2012-05-07protein level
2 26 18
2012-04-10protein level
2 26 18
2012-01-13protein level
2 9 18
2011-12-20protein level
2 9 18
2011-11-11protein level
2 9 18
2011-08-23protein level
1 9 18
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15085-1
1 64 0 167600.3504
NX_O15085-2
2 64 0 172136.7351
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-311099,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-311099,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
3 EBI-311099,EBI-446668 RHOA  
  .skeletal muscle satellite cell migration
.mitotic spindle assembly
.trabecula morphogenesis
  + 32 more...
.myosin binding
.GTP binding
.GTPase activity
.extracellular exosome
.apical junction complex
.cleavage furrow
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
bone27
brain18
cervix61
connective tissue20
ear62
embryonic tissue75
eye52
intestine64
kidney23
larynx127
liver14
lung56
lymph node11
mammary gland26
mouth45
nerve128
ovary78
pancreas46
pharynx220
placenta28
prostate42
skin56
stomach104
testis41
thyroid42
uterus47
Health State
TissuesTPM*
normal38
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma36
colorectal tumor62
gastrointestinal tumor67
germ cell tumor15
glioma18
head and neck tumor104
kidney tumor43
leukemia63
liver tumor10
lung tumor68
non-neoplasia41
ovarian tumor105
pancreatic tumor38
primitive neuroectodermal tumor of the CNS23
prostate cancer19
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor31
uterine tumor88
Developmental Stage
TissuesTPM*
adult55
embryoid body100
blastocyst97
fetus55
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.9
adrenal gland14
appendix14.7
bone marrow5.1
cerebral cortex16.3
colon14.8
duodenum15.5
esophagus12.9
gallbladder14.1
heart muscle11
kidney10
liver3.9
lung14.8
lymph node8.3
ovary14.6
pancreas6.6
placenta13.7
prostate10.6
salivary gland8.4
skin12.1
small intestine16.8
spleen14.5
stomach11.9
testis33.4
thyroid gland16.4
urinary bladder12.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateLow
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605708, gene) Rho guanine nucleotide exchange factor 11; ARHGEF11OMIM


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