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> Protein (NX_O15105)
Protein (NX_O15105)
Protein
Gene SymbolSMAD7 to neXtProt (NX_O15105)
DescriptionMothers against decapentaplegic homolog 7
Chromosome18
Location18q21.1 (46446223 ~ 46477081) to Ensembl
Sequene Features : Isoforms 3, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to transforming growth factor beta stimulus
.ventricular septum morphogenesis
.negative regulation of pathway-restricted SMAD protein phosphorylation
  + 32 more...
.I-SMAD binding
.activin binding
.metal ion binding
  + 6 more...
.protein complex
.plasma membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 25 5
2014-09-19protein level
3 19 5
2014-05-27protein level
3 18 5
2014-02-25protein level
3 18 5
2013-12-09protein level
3 15 5
2013-11-01protein level
3 15 5
2013-09-12protein level
3 15 5
2013-08-17protein level
3 15 5
2013-07-15protein level
2 11 5
2013-06-11protein level
2 11 5
2013-02-12protein level
2 6 6
2012-12-20protein level
1 6 5
2012-10-30protein level
1 7 5
2012-10-07protein level
1 7 5
2012-08-24protein level
1 5 5
2012-07-28protein level
1 5 5
2012-06-08protein level
1 11 5
2012-05-07protein level
1 11 5
2012-04-10protein level
1 11 5
2012-01-13protein level
1 9 5
2011-12-20protein level
1 9 5
2011-11-11protein level
1 9 5
2011-08-23protein level
1 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15105-1
1 21 0 46396.0061
NX_O15105-2
1 10 0 23885.6493
NX_O15105-3
1 21 0 46324.9692
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3861591,EBI-743923 WWP2  
  .regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 13 more...
.ligase activity
.transcription factor binding
.ubiquitin-protein transferase activity
.RNA polymerase II transcription factor binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
2 EBI-3861591,EBI-710484 AXIN1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.Wnt signaling pathway involved in somitogenesis
  + 45 more...
.I-SMAD binding
.armadillo repeat domain binding
.SMAD binding
  + 9 more...
.cell periphery
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 10 more...
3 EBI-3861591,EBI-1384128 ACVR1B  
  .positive regulation of trophoblast cell migration
.extrinsic apoptotic signaling pathway
.protein autophosphorylation
  + 18 more...
.metal ion binding
.SMAD binding
.inhibin binding
  + 6 more...
.extracellular exosome
.activin receptor complex
.receptor complex
  + 3 more...
4 EBI-3861591,EBI-1044059 YAP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of stem cell differentiation
.negative regulation of nucleic acid-templated transcription
  + 24 more...
.transcription regulatory region DNA binding
.transcription corepressor activity
.transcription coactivator activity
  + 3 more...
.cell junction
.membrane
.cytosol
  + 4 more...
5 EBI-3861591,EBI-1027571 FKBP1A  
  .amyloid fibril formation
.regulation of amyloid precursor protein catabolic process
.calcium ion transmembrane transport
  + 21 more...
.activin binding
.SMAD binding
.ion channel binding
  + 6 more...
.extracellular exosome
.Z disc
.membrane
  + 4 more...
6 EBI-3861591,EBI-594661 COPS5  
  .exosomal secretion
.regulation of IRE1-mediated unfolded protein response
.regulation of cell cycle
  + 8 more...
.metal ion binding
.metallopeptidase activity
.ubiquitin-specific protease activity
  + 2 more...
.perinuclear region of cytoplasm
.cell junction
.COP9 signalosome
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
bone41
brain10
cervix20
connective tissue6
embryonic tissue46
eye38
heart78
intestine8
kidney33
lung14
lymph node11
mammary gland13
muscle18
nerve128
pancreas18
pituitary gland60
placenta17
prostate15
thyroid64
uterus8
vascular77
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor21
chondrosarcoma12
colorectal tumor8
glioma9
head and neck tumor7
leukemia10
lung tumor9
non-neoplasia10
prostate cancer28
retinoblastoma21
uterine tumor11
Developmental Stage
TissuesTPM*
adult19
embryoid body85
blastocyst16
fetus16
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.9
adrenal gland7.6
appendix12
bone marrow19.7
cerebral cortex10.8
colon16.2
duodenum13.7
esophagus7.5
gallbladder17.8
heart muscle28.3
kidney20.6
liver8
lung37.7
lymph node11.5
ovary10.5
pancreas6
placenta25.6
prostate16.9
salivary gland9.6
skin3.1
small intestine20.8
spleen9.7
stomach17.7
testis2.6
thyroid gland25.6
urinary bladder22.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasLow
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602932, gene) Mothers against decapentaplegic, drosophila, homolog of, 7; SMAD7OMIM
2(#612229, phenotype) Colorectal cancer, susceptibility to, 3; CRCS3OMIM


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