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> Protein (NX_O15111)
Protein (NX_O15111)
Protein
Gene SymbolCHUK to neXtProt (NX_O15111)
DescriptionInhibitor of nuclear factor kappa-B kinase subunit alpha
Chromosome10
Location10q24.31 (101948055 ~ 101989376) to Ensembl
Sequene Features : Isoforms 1, Variants 68, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 68 4
2014-09-19protein level
1 51 4
2014-05-27protein level
1 51 4
2014-02-25protein level
1 51 4
2013-12-09protein level
1 43 4
2013-11-01protein level
1 41 4
2013-09-12protein level
1 41 4
2013-08-17protein level
1 41 4
2013-07-15protein level
1 20 4
2013-06-11protein level
1 20 4
2013-02-12protein level
1 10 4
2012-12-20protein level
1 10 4
2012-10-30protein level
1 13 4
2012-10-07protein level
1 13 4
2012-08-24protein level
1 9 4
2012-07-28protein level
1 9 4
2012-06-08protein level
1 21 4
2012-05-07protein level
1 21 4
2012-04-10protein level
1 21 4
2012-01-13protein level
1 20 4
2011-12-20protein level
1 20 4
2011-11-11protein level
1 20 3
2011-08-23protein level
1 20 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15111-1
34 0 2 84584.7215
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81249,EBI-81266 IKBKB  
  .positive regulation of cation channel activity
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
  + 32 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
2 EBI-81249,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
3 EBI-81249,EBI-296047 HSP90AA1  
  .regulation of cellular response to heat
.positive regulation of cardiac muscle contraction
.chaperone-mediated protein complex assembly
  + 26 more...
.GTPase binding
.poly(A) RNA binding
.protein homodimerization activity
  + 12 more...
.endocytic vesicle lumen
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
4 EBI-81249,EBI-307386 NFKBIA  
  .nucleotide-binding oligomerization domain containing 2 signaling pathway
.nucleotide-binding oligomerization domain containing 1 signaling pathway
.cellular response to cold
  + 39 more...
.NF-kappaB binding
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.I-kappaB/NF-kappaB complex
.plasma membrane
.cytosol
  + 2 more...
5 EBI-81249,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
6 EBI-81249,EBI-519280 CDKN1B  
  .mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
7 EBI-81249,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
8 EBI-81249,EBI-306914 FKBP5  
  .chaperone-mediated protein folding
.protein folding
.protein peptidyl-prolyl isomerization
.heat shock protein binding
.FK506 binding
.peptidyl-prolyl cis-trans isomerase activity
.extracellular exosome
.membrane
.endoplasmic reticulum membrane
.nucleoplasm
9 EBI-81249,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
10 EBI-81249,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
11 EBI-81249,EBI-968267 IRF7  
  .negative regulation of macrophage apoptotic process
.positive regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
  + 30 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter sequence-specific DNA binding
.endosome membrane
.cytosol
.cytoplasm
  + 2 more...
12 EBI-81249,EBI-358011 MAP3K14  
  .cellular response to mechanical stimulus
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 9 more...
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
  + 3 more...
.cytosol
.cytoplasm
13 EBI-81249,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder66
blood16
bone27
bone marrow102
brain19
cervix20
embryonic tissue37
eye9
heart11
intestine30
kidney37
larynx85
liver14
lung14
lymph node89
mammary gland39
muscle18
nerve128
pancreas23
parathyroid48
pharynx49
placenta35
salivary gland98
skin28
spleen18
stomach20
testis29
thymus25
trachea38
uterus21
Health State
TissuesTPM*
normal21
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor28
colorectal tumor26
gastrointestinal tumor16
germ cell tumor30
glioma27
head and neck tumor22
leukemia63
liver tumor10
lung tumor19
non-neoplasia10
primitive neuroectodermal tumor of the CNS31
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult23
embryoid body14
blastocyst65
fetus5
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.7
adrenal gland12.2
appendix14.6
bone marrow17.2
cerebral cortex10.2
colon14
duodenum13.8
esophagus10.8
gallbladder11.1
heart muscle5.8
kidney19.4
liver8.9
lung10.6
lymph node15
ovary6
pancreas5.6
placenta10.7
prostate10
salivary gland7.5
skin8.5
small intestine11.6
spleen9.9
stomach11.6
testis9.5
thyroid gland12.6
urinary bladder12
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600664, gene) Conserved helix-loop-helix ubiquitous kinase; CHUKOMIM
2(#613630, phenotype) Cocoon syndromeOMIM


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2014-2018 (C) Yonsei Proteome Research Center