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> Protein (NX_O15117)
Protein (NX_O15117)
Protein
Gene SymbolFYB to neXtProt (NX_O15117)
DescriptionFYN-binding protein
Chromosome5
Location5p13.1 (39105338 ~ 39274630) to Ensembl
Sequene Features : Isoforms 3, Variants 151, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.T cell receptor signaling pathway
.intracellular signal transduction
.signal transduction
  + 3 more...
.receptor binding .actin cytoskeleton
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 151 9
2014-09-19protein level
3 112 9
2014-05-27protein level
3 111 9
2014-02-25protein level
3 111 9
2013-12-09protein level
3 87 9
2013-11-01protein level
3 85 9
2013-09-12protein level
3 85 9
2013-08-17protein level
3 85 9
2013-07-15protein level
2 60 9
2013-06-11protein level
2 60 9
2013-02-12protein level
2 16 24
2012-12-20protein level
2 12 24
2012-10-30protein level
2 25 24
2012-10-07protein level
2 25 12
2012-08-24protein level
2 22 12
2012-07-28protein level
2 22 12
2012-06-08protein level
2 28 12
2012-05-07protein level
2 28 12
2012-04-10protein level
2 28 12
2012-01-13protein level
1 16 12
2011-12-20protein level
1 16 12
2011-11-11protein level
1 16 12
2011-08-23protein level
1 16 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15117-1
1 28 0 85334.8892
NX_O15117-2
0 31 0 90550.5424
NX_O15117-3
0 31 0 91595.0668
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1753267,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-1753267,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
3 EBI-1753267,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
4 EBI-1753267,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
5 EBI-1753267,EBI-2477305 SKAP1  
  .T cell receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of signal transduction
.SH2 domain binding
.protein phosphatase binding
.protein kinase binding
  + 2 more...
.cell-cell junction
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood122
bone marrow41
brain6
connective tissue13
eye19
heart55
intestine17
kidney23
liver4
lung2
lymph node22
mammary gland26
mouth15
muscle9
pancreas4
pharynx147
placenta24
prostate5
salivary gland49
skin9
spleen112
stomach52
thymus288
thyroid21
tonsil58
uterus25
vascular19
Health State
TissuesTPM*
normal15
adrenal tumor79
chondrosarcoma60
gastrointestinal tumor16
germ cell tumor49
glioma18
head and neck tumor14
kidney tumor14
leukemia10
lymphoma41
non-neoplasia20
ovarian tumor52
pancreatic tumor9
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor55
Developmental Stage
TissuesTPM*
adult4
neonate96
fetus1
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.7
adrenal gland5.2
appendix81.9
bone marrow32.4
cerebral cortex6.3
colon9.7
duodenum8.1
esophagus5.4
gallbladder17.8
heart muscle2.1
kidney3.3
liver6
lung12.4
lymph node74.7
ovary2.6
pancreas1.1
placenta12.9
prostate3.6
salivary gland4.8
skin1.4
small intestine13.2
spleen60.7
stomach13.6
testis3.8
thyroid gland2.8
urinary bladder24.7
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
lymph nodeMedium
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602731, gene) Fyn-binding protein; FYBOMIM


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