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> Protein (NX_O15118)
Protein (NX_O15118)
Protein
Gene SymbolNPC1 to neXtProt (NX_O15118)
DescriptionNiemann-Pick C1 protein
Chromosome18
Location18q11.2 (21086148 ~ 21166862) to Ensembl
Sequene Features : Isoforms 2, Variants 306, PTMs 25 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cholesterol homeostasis
.establishment of protein localization to membrane
.cellular response to low-density lipoprotein particle stimulus
  + 18 more...
.cholesterol binding
.sterol transporter activity
.hedgehog receptor activity
  + 2 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 306 25
2014-09-19protein level
1 269 25
2014-05-27protein level
1 269 25
2014-02-25protein level
1 268 25
2013-12-09protein level
1 247 25
2013-11-01protein level
1 240 25
2013-09-12protein level
1 240 15
2013-08-17protein level
1 240 15
2013-07-15protein level
1 217 9
2013-06-11protein level
1 217 9
2013-02-12protein level
1 194 9
2012-12-20protein level
1 194 9
2012-10-30protein level
1 199 9
2012-10-07protein level
1 199 9
2012-08-24protein level
1 195 11
2012-07-28protein level
1 195 11
2012-06-08protein level
1 197 11
2012-05-07protein level
1 197 11
2012-04-10protein level
1 197 11
2012-01-13protein level
1 184 11
2011-12-20protein level
1 184 11
2011-11-11protein level
1 184 11
2011-08-23protein level
1 184 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15118-1
14 32 0 142073.1628
NX_O15118-2
2 32 0 106954.6946
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland273
ascites25
blood98
bone55
bone marrow20
brain45
cervix82
connective tissue53
ear62
embryonic tissue14
esophagus49
eye81
heart11
intestine47
kidney52
liver19
lung56
lymph node44
mammary gland33
mouth45
ovary29
pancreas51
parathyroid48
placenta31
prostate58
salivary gland98
skin18
spleen37
stomach73
testis20
thymus50
thyroid85
trachea19
uterus56
vascular58
Health State
TissuesTPM*
normal55
adrenal tumor237
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma48
colorectal tumor44
esophageal tumor57
gastrointestinal tumor25
germ cell tumor15
glioma18
head and neck tumor29
kidney tumor29
leukemia148
lung tumor48
lymphoma69
non-neoplasia72
ovarian tumor26
pancreatic tumor85
primitive neuroectodermal tumor of the CNS47
prostate cancer67
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor23
uterine tumor77
Developmental Stage
TissuesTPM*
adult49
embryoid body28
blastocyst32
neonate64
fetus39
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.2
adrenal gland60.6
appendix20.4
bone marrow15.6
cerebral cortex30.6
colon12.8
duodenum14.8
esophagus16.6
gallbladder18.5
heart muscle6.6
kidney10
liver9.6
lung26.7
lymph node22.2
ovary15
pancreas6.4
placenta29.2
prostate14.7
salivary gland32
skin18.6
small intestine18.2
spleen19.3
stomach16.3
testis18.5
thyroid gland11.2
urinary bladder13
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#257220, phenotype) Niemann-pick disease, type c1; NPC1OMIM
2(*607623, gene) Npc1 gene; NPC1OMIM


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