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> Protein (NX_O15145)
Protein (NX_O15145)
Protein
Gene SymbolARPC3 to neXtProt (NX_O15145)
DescriptionActin-related protein 2/3 complex subunit 3
Chromosome12
Location12q24.11 (110872630 ~ 110888227) to Ensembl
Sequene Features : Isoforms 1, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ephrin receptor signaling pathway
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.structural constituent of cytoskeleton .extracellular exosome
.lamellipodium
.membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 15 7
2014-09-19protein level
1 13 7
2014-05-27protein level
1 13 7
2014-02-25protein level
1 13 7
2013-12-09protein level
1 9 7
2013-11-01protein level
1 8 6
2013-09-12protein level
1 8 6
2013-08-17protein level
1 8 6
2013-07-15protein level
1 4 3
2013-06-11protein level
1 4 3
2013-02-12protein level
1 3 3
2012-12-20protein level
1 3 3
2012-10-30protein level
1 4 3
2012-10-07protein level
1 4 3
2012-08-24protein level
1 3 3
2012-07-28protein level
1 3 3
2012-06-08protein level
1 4 3
2012-05-07protein level
1 4 3
2012-04-10protein level
1 4 3
2012-01-13protein level
1 3 3
2011-12-20protein level
1 3 3
2011-11-11protein level
1 3 3
2011-08-23protein level
1 3 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15145-1
6 0 0 20533.317
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351829,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
2 EBI-351829,EBI-8643838 HOXA3  
  .parathyroid gland development
.cartilage development
.embryonic skeletal system morphogenesis
  + 10 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
3 EBI-351829,EBI-746484 NRIP1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.circadian regulation of gene expression
  + 6 more...
.androgen receptor binding
.glucocorticoid receptor binding
.nuclear hormone receptor binding
  + 4 more...
.cell junction
.nuclear speck
.nucleolus
  + 3 more...
4 EBI-351829,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland273
ascites276
bladder267
blood212
bone83
bone marrow205
brain112
cervix123
connective tissue73
ear124
embryonic tissue98
eye129
heart100
intestine168
kidney99
larynx42
liver97
lung209
lymph45
lymph node311
mammary gland1011
mouth60
muscle47
nerve193
ovary59
pancreas379
parathyroid679
pharynx491
pituitary gland60
placenta91
prostate63
skin80
spleen37
stomach62
testis128
thyroid85
umbilical cord508
uterus129
vascular135
Health State
TissuesTPM*
normal134
adrenal tumor395
bladder carcinoma454
breast (mammary gland) tumor1622
cervical tumor115
chondrosarcoma120
colorectal tumor106
gastrointestinal tumor227
germ cell tumor72
glioma195
head and neck tumor74
kidney tumor87
leukemia201
liver tumor156
lung tumor116
lymphoma138
non-neoplasia103
ovarian tumor52
pancreatic tumor142
primitive neuroectodermal tumor of the CNS23
prostate cancer77
retinoblastoma236
skin tumor71
soft tissue/muscle tissue tumor79
uterine tumor188
Developmental Stage
TissuesTPM*
adult204
embryoid body128
blastocyst65
neonate225
fetus149
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue71
adrenal gland82.6
appendix170.8
bone marrow197.1
cerebral cortex79.7
colon116.2
duodenum100.8
esophagus112.8
gallbladder98.8
heart muscle47.9
kidney81.8
liver60.5
lung98.9
lymph node206.7
ovary43.8
pancreas34.3
placenta111
prostate71.9
salivary gland70.7
skin56.5
small intestine108.3
spleen174.6
stomach124.2
testis47.8
thyroid gland77
urinary bladder129.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604225, gene) Actin-related protein 2/3 complex, subunit 3; ARPC3OMIM


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