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> Protein (NX_O15151)
Protein (NX_O15151)
Protein
Gene SymbolMDM4 to neXtProt (NX_O15151)
DescriptionProtein Mdm4
Chromosome1
Location1q32.1 (204485511 ~ 204542871) to Ensembl
Sequene Features : Isoforms 5, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to hypoxia
.negative regulation of cell cycle arrest
.protein stabilization
  + 9 more...
.enzyme binding
.zinc ion binding
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 57 2
2014-09-19protein level
5 44 2
2014-05-27protein level
5 44 2
2014-02-25protein level
5 44 2
2013-12-09protein level
5 33 2
2013-11-01protein level
5 31 2
2013-09-12protein level
5 31 2
2013-08-17protein level
5 31 2
2013-07-15protein level
5 19 2
2013-06-11protein level
5 19 2
2013-02-12protein level
5 12 5
2012-12-20protein level
5 12 5
2012-10-30protein level
5 17 5
2012-10-07protein level
5 17 2
2012-08-24protein level
5 16 2
2012-07-28protein level
5 16 2
2012-06-08protein level
5 4 2
2012-05-07protein level
5 4 2
2012-04-10protein level
4 4 2
2012-01-13protein level
3 4 2
2011-12-20protein level
3 4 2
2011-11-11protein level
3 4 2
2011-08-23protein level
3 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15151-1
2 22 0 54829.4429
NX_O15151-2
1 6 0 14176.0542
NX_O15151-3
1 6 0 13971.8556
NX_O15151-4
1 7 0 18182.754
NX_O15151-5
1 22 0 49508.8578
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-398437,EBI-4314390 CD160  
  .defense response to Gram-negative bacterium
.regulation of immune response
.cell proliferation
  + 2 more...
.MHC class I receptor activity
.receptor binding
.receptor activity
.anchored component of plasma membrane
.plasma membrane
2 EBI-398437,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-398437,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
4 EBI-398437,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
5 EBI-398437,EBI-1383726 CSNK1A1  
  .positive regulation of canonical Wnt signaling pathway
.cell division
.peptidyl-serine phosphorylation
  + 7 more...
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.primary cilium
.nuclear speck
.membrane
  + 4 more...
6 EBI-398437,EBI-359832 YWHAG  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 14 more...
.poly(A) RNA binding
.protein kinase C inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase C binding
.extracellular exosome
.cytoplasmic vesicle membrane
.membrane
  + 2 more...
7 EBI-398437,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
8 EBI-398437,EBI-347677 UBE2D2  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 12 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.protein complex
.cytosol
  + 2 more...
9 EBI-398437,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
10 EBI-398437,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
11 EBI-398437,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
12 EBI-398437,EBI-2129242 RNF115  
  .protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 2 more...
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites50
bladder33
blood89
bone27
bone marrow41
brain34
connective tissue33
embryonic tissue14
esophagus49
eye38
heart33
intestine77
kidney42
larynx468
liver34
lung50
lymph node111
mammary gland85
mouth75
muscle56
nerve64
ovary49
pancreas18
pharynx73
pituitary gland60
placenta42
prostate36
salivary gland49
skin23
spleen37
stomach73
testis41
thymus677
thyroid171
trachea96
uterus64
vascular77
Health State
TissuesTPM*
normal46
bladder carcinoma56
breast (mammary gland) tumor96
chondrosarcoma36
colorectal tumor106
esophageal tumor57
gastrointestinal tumor42
germ cell tumor15
glioma37
head and neck tumor164
kidney tumor72
leukemia137
liver tumor52
non-neoplasia20
ovarian tumor65
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult56
embryoid body14
neonate32
fetus55
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.1
adrenal gland7.7
appendix14.4
bone marrow30.3
cerebral cortex6.3
colon7.4
duodenum6.1
esophagus5.7
gallbladder7.7
heart muscle4.6
kidney6.7
liver6.4
lung9.1
lymph node18.4
ovary8.8
pancreas3.4
placenta8.8
prostate7.6
salivary gland5.5
skin17.4
small intestine6.8
spleen16.7
stomach9.8
testis17.9
thyroid gland11.2
urinary bladder5.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumLow
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverHigh
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1High
soft tissue 2Medium
spleenMedium
stomach 1Low
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderLow
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602704, gene) Mouse double minute 4 homolog; MDM4OMIM
2GBM;bladder;retinoblastomaCGP


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