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> Protein (NX_O15156)
Protein (NX_O15156)
Protein
Gene SymbolZBTB7B to neXtProt (NX_O15156)
DescriptionZinc finger and BTB domain-containing protein 7B
Chromosome1
Location1q21.3 (154975127 ~ 154990998) to Ensembl
Sequene Features : Isoforms 2, Variants 75, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell differentiation
.positive regulation of gene expression
.ectoderm development
  + 3 more...
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 75 2
2014-09-19protein level
2 55 2
2014-05-27protein level
2 55 2
2014-02-25protein level
2 55 2
2013-12-09protein level
2 47 2
2013-11-01protein level
2 46 2
2013-09-12protein level
2 46 2
2013-08-17protein level
2 46 2
2013-07-15protein level
2 33 2
2013-06-11protein level
2 33 2
2013-02-12protein level
2 11 4
2012-12-20protein level
2 12 4
2012-10-30protein level
1 10 2
2012-10-07protein level
1 10 2
2012-08-24protein level
1 8 2
2012-07-28protein level
1 8 2
2012-06-08protein level
1 11 2
2012-05-07protein level
1 9 2
2012-04-10protein level
1 9 2
2012-01-13protein level
1 6 2
2011-12-20protein level
1 6 2
2011-11-11protein level
1 6 1
2011-08-23protein level
1 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15156-1
0 16 0 57990.0803
NX_O15156-2
1 16 0 61544.7747
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740434,EBI-722671 ZBTB5  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-740434,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
3 EBI-740434,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
4 EBI-740434,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
5 EBI-740434,EBI-765407 BCL6  
  .negative regulation of cellular senescence
.positive regulation of cellular component movement
.regulation of immune response
  + 32 more...
.metal ion binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 4 more...
.nucleus
6 EBI-740434,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
7 EBI-740434,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
8 EBI-740434,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
9 EBI-740434,EBI-747142 SYTL4  
  .multivesicular body sorting pathway
.positive regulation of protein secretion
.calcium ion-dependent exocytosis of neurotransmitter
  + 6 more...
.neurexin family protein binding
.clathrin binding
.syntaxin binding
  + 4 more...
.exocytic vesicle
.transport vesicle membrane
.secretory granule
  + 6 more...
10 EBI-740434,EBI-8641721 IMP4  
  .rRNA processing .rRNA primary transcript binding
.snoRNA binding
.Mpp10 complex
.small-subunit processome
.nucleolus
11 EBI-740434,EBI-722667 SH3YL1  
  .regulation of ruffle assembly
.phosphatidylinositol biosynthetic process
.phosphatidylinositol binding
.phosphatase binding
.ruffle membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood40
bone27
brain8
cervix41
connective tissue6
embryonic tissue14
eye33
heart33
intestine12
kidney9
larynx42
liver24
lung11
lymph22
lymph node11
mammary gland46
mouth15
muscle18
pancreas32
placenta38
prostate47
skin18
testis2
thymus25
trachea57
uterus30
Health State
TissuesTPM*
normal15
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma24
colorectal tumor8
gastrointestinal tumor25
germ cell tumor15
head and neck tumor14
leukemia52
liver tumor52
lung tumor29
lymphoma13
non-neoplasia41
pancreatic tumor38
prostate cancer77
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult29
embryoid body14
blastocyst16
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.3
adrenal gland17
appendix18.8
bone marrow21
cerebral cortex5.2
colon44.1
duodenum59.6
esophagus47.1
gallbladder14.7
heart muscle12.4
kidney18.5
liver9.3
lung17.8
lymph node16.7
ovary9
pancreas13.5
placenta12
prostate24.9
salivary gland28.6
skin71.5
small intestine66.6
spleen21.2
stomach31.6
testis6.3
thyroid gland16.6
urinary bladder19.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusMedium
cerebellumMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
esophagusHigh
gallbladderHigh
lymph nodeLow
nasopharynxMedium
oral mucosaHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
stomach 1High
stomach 2High
testisLow
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607646, gene) Zinc finger- and btb domain-containing protein 7b; ZBTB7BOMIM


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