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> Protein (NX_O15160)
Protein (NX_O15160)
Protein
Gene SymbolPOLR1C to neXtProt (NX_O15160)
DescriptionDNA-directed RNA polymerases I and III subunit RPAC1
Chromosome6
Location6p21.1 (43477440 ~ 43497323) to Ensembl
Sequene Features : Isoforms 2, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 50 5
2014-09-19protein level
2 45 5
2014-05-27protein level
2 45 5
2014-02-25protein level
2 43 5
2013-12-09protein level
2 34 5
2013-11-01protein level
2 32 3
2013-09-12protein level
2 32 3
2013-08-17protein level
2 32 3
2013-07-15protein level
2 21 2
2013-06-11protein level
2 21 2
2013-02-12protein level
2 18 6
2012-12-20protein level
2 18 6
2012-10-30protein level
2 20 6
2012-10-07protein level
2 20 3
2012-08-24protein level
2 19 3
2012-07-28protein level
2 19 3
2012-06-08protein level
2 19 3
2012-05-07protein level
2 17 3
2012-04-10protein level
2 17 3
2012-01-13protein level
2 9 3
2011-12-20protein level
2 9 3
2011-11-11protein level
2 9 3
2011-08-23protein level
2 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15160-1
2 13 0 39224.9161
NX_O15160-2
1 13 0 38622.5072
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1055079,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
2 EBI-1055079,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-1055079,EBI-741141 NME1  
  .cellular response to fatty acid
.cellular response to glucose stimulus
.nucleobase-containing small molecule metabolic process
  + 22 more...
.poly(A) RNA binding
.ribosomal small subunit binding
.identical protein binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.ruffle membrane
  + 7 more...
4 EBI-1055079,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
5 EBI-1055079,EBI-394753 POLR2J  
  .positive regulation of viral transcription
.somatic stem cell maintenance
.piRNA metabolic process
  + 11 more...
.LRR domain binding
.DNA-directed RNA polymerase activity
.DNA binding
.DNA-directed RNA polymerase II, core complex
.nucleoplasm
.nucleus
6 EBI-1055079,EBI-2505861 TNFAIP1  
  .protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 8 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.endosome
.cytoplasm
.nucleolus
7 EBI-1055079,EBI-395421 SMN2  
  .ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
8 EBI-1055079,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
9 EBI-1055079,EBI-9027502 KCTD1  
  .protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
10 EBI-1055079,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
11 EBI-1055079,EBI-747353 ATRIP  
  .DNA repair
.DNA replication
.DNA damage checkpoint
.K63-linked polyubiquitin binding .nucleoplasm
.nucleus
12 EBI-1055079,EBI-2561661 PPP2R3C  
  .regulation of mitochondrial depolarization
.spleen development
.positive regulation of B cell differentiation
  + 6 more...
.metal ion binding .spindle
.centrosome
.cytoplasm
.nucleus
13 EBI-1055079,EBI-517623 BIRC7  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.regulation of natural killer cell apoptotic process
.negative regulation of apoptotic process
  + 4 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.enzyme binding
.ligase activity
  + 3 more...
.Golgi apparatus
.cytoplasm
.nucleus
14 EBI-1055079,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
15 EBI-1055079,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
16 EBI-1055079,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
17 EBI-1055079,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
18 EBI-1055079,EBI-359498 POLR1D  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
19 EBI-1055079,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites100
bladder66
blood139
bone111
bone marrow41
brain32
cervix123
connective tissue6
embryonic tissue79
esophagus49
eye43
heart55
intestine30
kidney52
liver68
lung47
lymph90
lymph node11
mammary gland39
mouth30
muscle18
ovary68
pancreas18
pharynx98
placenta49
prostate36
salivary gland49
skin90
stomach104
testis39
trachea19
umbilical cord145
uterus64
vascular19
Health State
TissuesTPM*
normal37
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma84
colorectal tumor17
esophageal tumor57
gastrointestinal tumor109
germ cell tumor68
glioma46
head and neck tumor14
kidney tumor29
leukemia74
liver tumor52
lung tumor58
lymphoma96
non-neoplasia20
ovarian tumor39
pancreatic tumor28
primitive neuroectodermal tumor of the CNS62
prostate cancer28
retinoblastoma86
skin tumor127
soft tissue/muscle tissue tumor23
uterine tumor77
Developmental Stage
TissuesTPM*
adult37
embryoid body71
blastocyst48
neonate64
fetus35
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.2
adrenal gland19.8
appendix18.3
bone marrow18.8
cerebral cortex14.3
colon19.9
duodenum16
esophagus19.8
gallbladder14.9
heart muscle8.1
kidney18.6
liver15.3
lung13.4
lymph node20
ovary20.3
pancreas9.2
placenta16.4
prostate16.6
salivary gland15.8
skin23.8
small intestine13.1
spleen15.9
stomach16.6
testis23.5
thyroid gland21
urinary bladder17.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#248390, phenotype) Treacher collins syndrome 3; TCS3OMIM
2(*610060, gene) Polymerase i, rna, subunit c; POLR1COMIM


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