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> Protein (NX_O15165)
Protein (NX_O15165)
Protein
Gene SymbolLDLRAD4 to neXtProt (NX_O15165)
DescriptionLow-density lipoprotein receptor class A domain-containing protein 4
Chromosome18
Location18p11.21 (13217497 ~ 13652754) to Ensembl
Sequene Features : Isoforms 8, Variants 13, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of pathway-restricted SMAD protein phosphorylation
.negative regulation of transforming growth factor beta receptor signaling pathway
.negative regulation of cell migration
  + 2 more...
.R-SMAD binding .early endosome membrane
.integral component of membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 13 2
2014-09-19protein level
8 54 2
2014-05-27protein level
8 54 2
2014-02-25protein level
7 54 2
2013-12-09protein level
7 46 2
2013-11-01protein level
7 44 2
2013-09-12protein level
7 44 2
2013-08-17protein level
7 44 2
2013-07-15transcript level
7 27 2
2013-06-11transcript level
7 27 2
2013-02-12transcript level
7 12 4
2012-12-20transcript level
7 12 4
2012-10-30transcript level
6 13 4
2012-10-07transcript level
6 13 2
2012-08-24transcript level
6 12 2
2012-07-28transcript level
6 12 2
2012-06-08transcript level
6 15 2
2012-05-07transcript level
6 8 2
2012-04-10transcript level
5 8 2
2012-01-13transcript level
5 5 2
2011-12-20transcript level
5 5 2
2011-11-11transcript level
5 5 2
2011-08-23transcript level
5 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15165-1
0 11 0 33878.3653
NX_O15165-2
0 10 0 32051.5445
NX_O15165-3
0 10 0 27582.6506
NX_O15165-4
0 9 0 25755.8298
NX_O15165-5
1 9 0 25543.4824
NX_O15165-6
0 11 0 30055.94
NX_O15165-7
0 10 0 28229.1192
NX_O15165-8
1 7 0 23038.0346
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood16
bone13
bone marrow61
brain126
connective tissue13
eye19
heart33
intestine8
kidney42
larynx42
liver9
lung35
lymph node33
mammary gland13
mouth15
muscle56
nerve128
ovary9
pancreas9
pharynx49
pituitary gland60
placenta24
prostate84
skin4
spleen37
testis25
thymus238
thyroid85
trachea57
umbilical cord72
uterus34
vascular19
Health State
TissuesTPM*
normal69
breast (mammary gland) tumor10
germ cell tumor7
glioma18
head and neck tumor37
kidney tumor87
leukemia31
lung tumor19
lymphoma13
non-neoplasia113
pancreatic tumor9
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult31
neonate32
fetus61
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.6
adrenal gland7.2
appendix10.5
bone marrow8.2
cerebral cortex25.9
colon8.4
duodenum8.7
esophagus5
gallbladder9.8
heart muscle11.1
kidney4.4
liver17.7
lung5
lymph node9.5
ovary1.7
pancreas2
placenta8.9
prostate22.4
salivary gland2.8
skin1.3
small intestine8.7
spleen8.4
stomach7.6
testis7.2
thyroid gland4.2
urinary bladder11.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606571, gene) Chromosome 18 open reading frame 1; C18ORF1OMIM


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