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> Protein (NX_O15169)
Protein (NX_O15169)
Protein
Gene SymbolAXIN1 to neXtProt (NX_O15169)
DescriptionAxin-1
Chromosome16
Location16p13.3 (337440 ~ 402673) to Ensembl
Sequene Features : Isoforms 2, Variants 196, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.Wnt signaling pathway involved in somitogenesis
  + 45 more...
.I-SMAD binding
.armadillo repeat domain binding
.SMAD binding
  + 9 more...
.cell periphery
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 196 11
2014-09-19protein level
2 175 11
2014-05-27protein level
2 175 12
2014-02-25protein level
2 174 12
2013-12-09protein level
2 157 12
2013-11-01protein level
2 149 12
2013-09-12protein level
2 149 12
2013-08-17protein level
2 149 12
2013-07-15protein level
2 137 12
2013-06-11protein level
2 137 12
2013-02-12protein level
2 119 22
2012-12-20protein level
2 119 22
2012-10-30protein level
2 119 22
2012-10-07protein level
2 119 11
2012-08-24protein level
2 24 11
2012-07-28protein level
2 24 11
2012-06-08protein level
2 28 11
2012-05-07protein level
2 22 11
2012-04-10protein level
2 22 11
2012-01-13protein level
2 14 11
2011-12-20protein level
2 14 11
2011-11-11protein level
2 14 12
2011-08-23protein level
2 14 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15169-1
1 38 0 95575.3241
NX_O15169-2
0 38 0 91596.3666
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-710484,EBI-3861591 SMAD7  
  .cellular response to transforming growth factor beta stimulus
.ventricular septum morphogenesis
.negative regulation of pathway-restricted SMAD protein phosphorylation
  + 32 more...
.I-SMAD binding
.activin binding
.metal ion binding
  + 6 more...
.protein complex
.plasma membrane
.cytosol
  + 4 more...
2 EBI-710484,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
3 EBI-710484,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-710484,EBI-302589 TUBG1  
  .cytoplasmic microtubule organization
.microtubule nucleation
.organelle organization
  + 4 more...
.GTP binding
.structural constituent of cytoskeleton
.GTPase activity
.recycling endosome
.cytosol
.polar microtubule
  + 4 more...
5 EBI-710484,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
6 EBI-710484,EBI-989143 PPM1A  
  .positive regulation of transcription, DNA-templated
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 16 more...
.R-SMAD binding
.calmodulin-dependent protein phosphatase activity
.manganese ion binding
  + 3 more...
.neuron projection
.membrane
.voltage-gated calcium channel complex
  + 3 more...
7 EBI-710484,EBI-359234 ANP32A  
  .intracellular signal transduction
.gene expression
.nucleocytoplasmic transport
  + 2 more...
.poly(A) RNA binding .perinuclear region of cytoplasm
.endoplasmic reticulum
.cytoplasm
  + 2 more...
8 EBI-710484,EBI-1044059 YAP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of stem cell differentiation
.negative regulation of nucleic acid-templated transcription
  + 24 more...
.transcription regulatory region DNA binding
.transcription corepressor activity
.transcription coactivator activity
  + 3 more...
.cell junction
.membrane
.cytosol
  + 4 more...
9 EBI-710484,EBI-749343 CSNK1E  
  .positive regulation of canonical Wnt signaling pathway
.regulation of circadian rhythm
.cellular protein localization
  + 14 more...
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.ribonucleoprotein complex
.cytosol
.cytoplasm
.nucleus
10 EBI-710484,EBI-1044067 GSK3A  
  .positive regulation of glycogen (starch) synthase activity
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 33 more...
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
.ATP binding
.protein serine/threonine kinase activity
.beta-catenin destruction complex
.cytosol
11 EBI-710484,EBI-373586 GSK3B  
  .positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
12 EBI-710484,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
13 EBI-710484,EBI-702370 TRIM29  
  .negative regulation of protein localization to nucleus
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
14 EBI-710484,EBI-473101 CRMP1  
  .axon guidance
.nervous system development
.nucleobase-containing compound metabolic process
.microtubule cytoskeleton organization
.hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds .neuronal cell body
.dendrite
.cytosol
  + 3 more...
15 EBI-710484,EBI-9543020 DAB2IP  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron migration
.negative regulation of cyclin catabolic process
  + 69 more...
.14-3-3 protein binding
.phosphatidylinositol-4-phosphate binding
.protein phosphatase 2A binding
  + 15 more...
.AIP1-IRE1 complex
.parallel fiber
.extracellular exosome
  + 10 more...
16 EBI-710484,EBI-2129175 RNF111  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of protein ubiquitination
  + 9 more...
.ubiquitin protein ligase activity
.SUMO polymer binding
.ligase activity
.zinc ion binding
.protein complex
.cytoplasm
.nucleolus
  + 2 more...
17 EBI-710484,EBI-4398527 TNKS2  
  .positive regulation of canonical Wnt signaling pathway
.protein auto-ADP-ribosylation
.protein localization to chromosome, telomeric region
  + 6 more...
.metal ion binding
.enzyme binding
.NAD+ ADP-ribosyltransferase activity
.perinuclear region of cytoplasm
.cytosol
.cytoplasm
  + 5 more...
18 EBI-710484,EBI-355189 FBXW11  
  .rhythmic process
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 14 more...
.ubiquitin-protein transferase activity .SCF ubiquitin ligase complex
.cytosol
.centrosome
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood57
bone27
bone marrow20
brain14
cervix164
embryonic tissue32
eye4
intestine51
kidney14
liver4
lung29
lymph67
lymph node55
mammary gland19
mouth15
muscle18
ovary29
pancreas14
placenta7
prostate5
salivary gland49
skin28
spleen18
stomach41
testis16
thyroid85
tonsil58
uterus47
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor21
cervical tumor115
chondrosarcoma48
colorectal tumor79
gastrointestinal tumor33
germ cell tumor15
glioma65
head and neck tumor44
kidney tumor29
leukemia95
liver tumor10
lung tumor29
lymphoma41
ovarian tumor39
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
prostate cancer9
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor23
uterine tumor77
Developmental Stage
TissuesTPM*
adult26
embryoid body57
blastocyst48
fetus17
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.9
adrenal gland5
appendix8.6
bone marrow13.3
cerebral cortex4.9
colon11.6
duodenum10.2
esophagus7.1
gallbladder6.7
heart muscle4
kidney6.2
liver2.7
lung8.7
lymph node9.5
ovary7.8
pancreas5.5
placenta5.7
prostate6.7
salivary gland7.1
skin10.5
small intestine10.7
spleen12
stomach11
testis9.1
thyroid gland6.4
urinary bladder6.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleHigh
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#114550, phenotype) Hepatocellular carcinomaOMIM
2(*603816, gene) Axis inhibitor 1; AXIN1OMIM
3(#607864, phenotype) Caudal duplication anomalyOMIM


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