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> Protein (NX_O15197)
Protein (NX_O15197)
Protein
Gene SymbolEPHB6 to neXtProt (NX_O15197)
DescriptionEphrin type-B receptor 6
Chromosome7
Location7q34 (142552792 ~ 142568847) to Ensembl
Sequene Features : Isoforms 3, Variants 195, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ephrin receptor signaling pathway
.axon guidance
.ATP binding
.ephrin receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.cytosol
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 195 1
2014-09-19protein level
3 154 1
2014-05-27protein level
3 154 1
2014-02-25protein level
3 154 1
2013-12-09protein level
3 133 1
2013-11-01protein level
3 129 1
2013-09-12protein level
3 129 1
2013-08-17protein level
3 129 1
2013-07-15protein level
3 98 1
2013-06-11protein level
3 98 1
2013-02-12protein level
3 47 3
2012-12-20protein level
3 48 3
2012-10-30protein level
3 52 3
2012-10-07protein level
3 52 1
2012-08-24protein level
3 51 1
2012-07-28protein level
3 49 1
2012-06-08protein level
3 49 1
2012-05-07protein level
3 30 1
2012-04-10protein level
3 30 1
2012-01-13protein level
3 26 1
2011-12-20protein level
3 26 1
2011-11-11protein level
3 26 1
2011-08-23protein level
3 26 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15197-1
0 45 0 110629.9807
NX_O15197-2
1 32 0 81159.6344
NX_O15197-3
3 21 0 57460.9717
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10182490,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
2 EBI-10182490,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-10182490,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
4 EBI-10182490,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
5 EBI-10182490,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
6 EBI-10182490,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder66
blood24
bone13
brain36
connective tissue6
embryonic tissue28
eye28
heart22
kidney9
liver4
lung2
lymph node11
mammary gland13
muscle9
nerve64
ovary19
pancreas28
prostate26
skin66
testis20
thymus37
tonsil117
uterus12
Health State
TissuesTPM*
normal27
bladder carcinoma113
chondrosarcoma12
leukemia31
non-neoplasia10
ovarian tumor13
pancreatic tumor57
Developmental Stage
TissuesTPM*
adult24
embryoid body14
blastocyst65
fetus19
infant212
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.7
adrenal gland1.8
appendix6.1
bone marrow5.1
cerebral cortex30.5
colon2.3
duodenum1.3
esophagus16.7
gallbladder6.5
heart muscle2
kidney2.9
liver1.1
lung5.4
lymph node10.5
ovary12.6
pancreas10.4
placenta2.1
prostate18
salivary gland8.1
skin156.9
small intestine2.2
spleen5.9
stomach4
testis12.7
thyroid gland14.1
urinary bladder9.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602757, gene) Ephrin receptor ephb6; EPHB6OMIM


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