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> Protein (NX_O15304)
Protein (NX_O15304)
Protein
Gene SymbolSIVA1 to neXtProt (NX_O15304)
DescriptionApoptosis regulatory protein Siva
Chromosome14
Location14q32.33 (105219437 ~ 105234831) to Ensembl
Sequene Features : Isoforms 2, Variants 17, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 3 more...
.metal ion binding
.zinc ion binding
.CD27 receptor binding
.virus receptor activity
.mitochondrion
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 17 4
2014-09-19protein level
2 15 4
2014-05-27protein level
2 15 4
2014-02-25protein level
2 15 4
2013-12-09protein level
2 11 4
2013-11-01protein level
2 9 4
2013-09-12protein level
2 9 4
2013-08-17protein level
2 9 4
2013-07-15protein level
2 5 1
2013-06-11protein level
2 5 1
2013-02-12protein level
2 4 2
2012-12-20protein level
2 4 2
2012-10-30protein level
2 5 2
2012-10-07protein level
2 5 1
2012-08-24protein level
2 4 1
2012-07-28protein level
2 4 1
2012-06-08protein level
2 6 1
2012-05-07protein level
2 6 1
2012-04-10protein level
2 6 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 6 1
2011-11-11protein level
2 6 1
2011-08-23protein level
2 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15304-1
4 5 0 18681.9775
NX_O15304-2
1 5 0 11769.3793
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-520756,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
2 EBI-520756,EBI-520729 CD27  
  .extrinsic apoptotic signaling pathway
.negative regulation of T cell apoptotic process
.positive regulation of JNK cascade
  + 7 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.transmembrane signaling receptor activity
.extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
.extracellular region
3 EBI-520756,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
4 EBI-520756,EBI-1392944 PXMP2  
  .N/A .N/A .protein complex
.integral component of membrane
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone41
brain53
connective tissue6
embryonic tissue61
eye28
heart44
intestine51
kidney28
liver77
lung101
lymph135
lymph node33
mammary gland39
mouth30
muscle65
ovary68
pancreas121
parathyroid97
placenta123
prostate73
salivary gland148
skin75
stomach41
testis137
thymus250
tonsil293
trachea38
uterus68
Health State
TissuesTPM*
normal50
breast (mammary gland) tumor53
chondrosarcoma12
colorectal tumor35
gastrointestinal tumor25
germ cell tumor56
glioma102
head and neck tumor37
kidney tumor43
leukemia31
liver tumor114
lung tumor87
lymphoma83
non-neoplasia20
ovarian tumor52
pancreatic tumor57
primitive neuroectodermal tumor of the CNS78
prostate cancer77
skin tumor111
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult47
embryoid body100
blastocyst16
fetus62
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.1
adrenal gland23.3
appendix27.7
bone marrow69.1
cerebral cortex13.3
colon31.3
duodenum36.7
esophagus20.9
gallbladder27.3
heart muscle30.1
kidney35
liver26.5
lung28.9
lymph node38.7
ovary26.4
pancreas38.6
placenta31
prostate40.6
salivary gland43
skin23.9
small intestine35.8
spleen45.5
stomach35.8
testis42.5
thyroid gland29.9
urinary bladder19.5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*605567, gene) Siva apoptosis-inducing factor 1; SIVA1OMIM


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