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> Protein (NX_O15305)
Protein (NX_O15305)
Protein
Gene SymbolPMM2 to neXtProt (NX_O15305)
DescriptionPhosphomannomutase 2
Chromosome16
Location16p13.2 (8882680 ~ 8943188) to Ensembl
Sequene Features : Isoforms 2, Variants 97, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.post-translational protein modification
.mannose biosynthetic process
  + 4 more...
.phosphomannomutase activity .extracellular exosome
.neuronal cell body
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 97 3
2014-09-19protein level
1 92 3
2014-05-27protein level
1 92 3
2014-02-25protein level
1 92 3
2013-12-09protein level
1 86 3
2013-11-01protein level
1 86 1
2013-09-12protein level
1 86 0
2013-08-17protein level
1 86 0
2013-07-15protein level
1 78 0
2013-06-11protein level
1 78 0
2013-02-12protein level
1 75 0
2012-12-20protein level
1 75 0
2012-10-30protein level
1 78 0
2012-10-07protein level
1 78 0
2012-08-24protein level
1 77 0
2012-07-28protein level
1 77 0
2012-06-08protein level
1 77 0
2012-05-07protein level
1 76 0
2012-04-10protein level
1 76 0
2012-01-13protein level
1 71 0
2011-12-20protein level
1 71 0
2011-11-11protein level
1 71 0
2011-08-23protein level
1 71 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15305-1
7 6 0 28064.1489
NX_O15305-2
0 6 0 13419.1334
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10182608,EBI-3916242 ACY3  
  .small molecule metabolic process
.viral process
.xenobiotic metabolic process
.metal ion binding
.hydrolase activity, acting on ester bonds
.aminoacylase activity
.extracellular exosome
.apical plasma membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder100
blood106
bone13
bone marrow20
brain47
cervix82
connective tissue107
embryonic tissue61
esophagus99
eye19
heart89
intestine215
kidney147
larynx42
liver131
lung56
lymph45
mammary gland112
mouth241
muscle37
ovary39
pancreas89
placenta123
prostate68
skin151
spleen112
stomach73
testis50
thymus37
thyroid21
trachea115
uterus94
vascular271
Health State
TissuesTPM*
normal61
breast (mammary gland) tumor182
cervical tumor115
chondrosarcoma72
colorectal tumor302
esophageal tumor115
gastrointestinal tumor67
germ cell tumor129
glioma111
head and neck tumor119
kidney tumor101
leukemia84
liver tumor208
lung tumor48
lymphoma27
non-neoplasia62
ovarian tumor13
pancreatic tumor142
primitive neuroectodermal tumor of the CNS110
prostate cancer28
retinoblastoma86
skin tumor151
soft tissue/muscle tissue tumor39
uterine tumor88
Developmental Stage
TissuesTPM*
adult78
embryoid body100
blastocyst32
neonate193
fetus26
juvenile323
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.5
adrenal gland10.3
appendix21.4
bone marrow6
cerebral cortex4.6
colon31.1
duodenum28.2
esophagus18.5
gallbladder16.4
heart muscle9.6
kidney10.5
liver14.3
lung13.7
lymph node17.9
ovary9.2
pancreas16.9
placenta20.6
prostate13.5
salivary gland17.5
skin9.2
small intestine25.1
spleen11.5
stomach24.6
testis7.8
thyroid gland12
urinary bladder21.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#212065, phenotype) Congenital disorder of glycosylation, type ia; CDG1AOMIM
2(*601785, gene) Phosphomannomutase 2; PMM2OMIM


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