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> Protein (NX_O15315)
Protein (NX_O15315)
Protein
Gene SymbolRAD51B to neXtProt (NX_O15315)
DescriptionDNA repair protein RAD51 homolog 2
Chromosome14
Location14q24.1 (68286496 ~ 69196935) to Ensembl
Sequene Features : Isoforms 5, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of G2/M transition of mitotic cell cycle
.blood coagulation
.reciprocal meiotic recombination
  + 3 more...
.DNA-dependent ATPase activity
.ATP binding
.single-stranded DNA binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.replication fork
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 44 0
2014-09-19protein level
5 39 0
2014-05-27protein level
5 39 0
2014-02-25protein level
5 38 0
2013-12-09protein level
5 30 0
2013-11-01protein level
5 29 0
2013-09-12protein level
5 29 0
2013-08-17protein level
5 29 0
2013-07-15protein level
5 24 0
2013-06-11protein level
5 24 0
2013-02-12protein level
5 18 0
2012-12-20protein level
5 17 0
2012-10-30protein level
5 20 0
2012-10-07protein level
5 20 0
2012-08-24protein level
5 20 0
2012-07-28protein level
5 20 0
2012-06-08protein level
5 9 0
2012-05-07protein level
5 9 0
2012-04-10protein level
5 9 0
2012-01-13protein level
5 9 0
2011-12-20protein level
5 9 0
2011-11-11protein level
5 9 0
2011-08-23protein level
5 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15315-1
1 14 0 38232.5969
NX_O15315-2
0 15 0 38279.6701
NX_O15315-3
1 14 0 42168.5274
NX_O15315-4
1 14 0 40258.6007
NX_O15315-5
1 9 0 25511.2753
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2824089,EBI-2267048 RAD51C  
  .positive regulation of G2/M transition of mitotic cell cycle
.blood coagulation
.spermatogenesis
  + 8 more...
.crossover junction endodeoxyribonuclease activity
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.perinuclear region of cytoplasm
.Rad51C-XRCC3 complex
.Rad51B-Rad51C-Rad51D-XRCC2 complex
  + 5 more...
2 EBI-2824089,EBI-1055693 RAD51D  
  .strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
3 EBI-2824089,EBI-5281637 SWSAP1  
  .protein stabilization
.double-strand break repair via homologous recombination
.ATPase activity
.single-stranded DNA binding
.Shu complex
.nucleus
4 EBI-2824089,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood49
bone41
bone marrow20
brain8
connective tissue87
kidney4
mammary gland33
muscle18
ovary19
pancreas28
pharynx24
placenta21
testis13
thymus25
thyroid21
trachea19
uterus30
vascular19
Health State
TissuesTPM*
normal13
breast (mammary gland) tumor21
chondrosarcoma36
head and neck tumor7
kidney tumor14
leukemia31
lymphoma69
primitive neuroectodermal tumor of the CNS39
soft tissue/muscle tissue tumor119
uterine tumor22
Developmental Stage
TissuesTPM*
adult20
fetus14
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.7
adrenal gland5.8
appendix5.9
bone marrow7.2
cerebral cortex4.3
colon6
duodenum2.8
esophagus10.5
gallbladder23.4
heart muscle4.4
kidney6.1
liver2.6
lung5.1
lymph node10.8
ovary19.6
pancreas2.9
placenta7.6
prostate9.7
salivary gland22.4
skin7.3
small intestine4.5
spleen4.2
stomach4.1
testis4
thyroid gland11.8
urinary bladder18.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#150699, phenotype) Leiomyoma, uterine; ULOMIM
2(*602948, gene) Rad51, s. cerevisiae, homolog of, b; RAD51L1OMIM


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