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> Protein (NX_O15344)
Protein (NX_O15344)
Protein
Gene SymbolMID1 to neXtProt (NX_O15344)
DescriptionE3 ubiquitin-protein ligase Midline-1
ChromosomeX
LocationXp22.2 (10413350 ~ 10851773) to Ensembl
Sequene Features : Isoforms 2, Variants 81, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 81 4
2014-09-19protein level
2 70 4
2014-05-27protein level
2 70 4
2014-02-25protein level
2 70 4
2013-12-09protein level
2 64 4
2013-11-01protein level
2 61 3
2013-09-12protein level
2 61 3
2013-08-17protein level
2 61 3
2013-07-15protein level
2 38 3
2013-06-11protein level
2 38 3
2013-02-12protein level
2 21 8
2012-12-20protein level
2 21 8
2012-10-30protein level
2 21 8
2012-10-07protein level
2 21 4
2012-08-24protein level
2 12 4
2012-07-28protein level
2 12 4
2012-06-08protein level
2 14 4
2012-05-07protein level
2 14 4
2012-04-10protein level
2 14 4
2012-01-13protein level
2 11 4
2011-12-20protein level
2 11 4
2011-11-11protein level
2 11 4
2011-08-23protein level
2 11 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15344-1
6 23 2 75202.3776
NX_O15344-2
1 23 2 62247.8865
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2340316,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
2 EBI-2340316,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
3 EBI-2340316,EBI-348268 UBE2D3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to hypoxia
.protein K11-linked ubiquitination
  + 24 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.endosome membrane
.plasma membrane
  + 2 more...
4 EBI-2340316,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
5 EBI-2340316,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
6 EBI-2340316,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
7 EBI-2340316,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
8 EBI-2340316,EBI-348496 UBE2E3  
  .protein K11-linked ubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.regulation of growth
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleus
9 EBI-2340316,EBI-746259 OTUB2  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.protein K11-linked deubiquitination
.protein deubiquitination
.ubiquitin-specific protease activity .nucleus
10 EBI-2340316,EBI-2129763 UBE2E2  
  .positive regulation of G1/S transition of mitotic cell cycle
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 3 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.N/A
11 EBI-2340316,EBI-745871 UBTD1  
  .N/A .N/A .N/A
12 EBI-2340316,EBI-3914009 DYRK4  
  .N/A .metal ion binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.intracellular membrane-bounded organelle
.cytoplasm
.nucleus
13 EBI-2340316,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
bone13
bone marrow20
brain53
connective tissue53
ear124
embryonic tissue145
eye33
heart67
intestine30
kidney18
larynx85
liver53
lung71
mammary gland13
mouth166
muscle37
nerve64
ovary29
parathyroid145
pharynx24
placenta52
prostate15
skin23
stomach10
testis94
thymus50
trachea231
uterus38
Health State
TissuesTPM*
normal62
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma84
colorectal tumor17
gastrointestinal tumor16
germ cell tumor136
glioma46
head and neck tumor7
kidney tumor43
liver tumor31
lung tumor19
non-neoplasia20
primitive neuroectodermal tumor of the CNS15
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult1
embryoid body228
blastocyst146
neonate32
fetus122
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.6
adrenal gland3
appendix6.2
cerebral cortex5.2
colon10.6
duodenum7
esophagus11.3
gallbladder10.3
heart muscle7.6
kidney6.3
liver2.8
lung8.4
lymph node2.1
ovary6
pancreas2.1
placenta7.1
prostate9.2
salivary gland3.3
skin2.7
small intestine7.2
stomach4
testis5.7
thyroid gland5.3
urinary bladder12.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#300000, phenotype) Opitz gbbb syndrome, x-linkedOMIM
2(*300552, gene) Midline 1; MID1OMIM


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