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> Protein (NX_O15350)
Protein (NX_O15350)
Protein
Gene SymbolTP73 to neXtProt (NX_O15350)
DescriptionTumor protein p73
Chromosome1
Location1p36.32 (3569084 ~ 3652765) to Ensembl
Sequene Features : Isoforms 12, Variants 62, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.negative regulation of cardiac muscle cell proliferation
.protein tetramerization
  + 31 more...
.metal ion binding
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.intracellular membrane-bounded organelle
.cell junction
.cytosol
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
12 62 4
2014-09-19protein level
12 42 4
2014-05-27protein level
12 42 4
2014-02-25protein level
10 42 4
2013-12-09protein level
10 31 4
2013-11-01protein level
10 30 4
2013-09-12protein level
10 30 4
2013-08-17protein level
10 30 4
2013-07-15protein level
10 21 4
2013-06-11protein level
10 21 4
2013-02-12protein level
10 7 23
2012-12-20protein level
9 10 22
2012-10-30protein level
9 13 22
2012-10-07protein level
9 13 4
2012-08-24protein level
9 12 4
2012-07-28protein level
9 12 4
2012-06-08protein level
9 4 4
2012-05-07protein level
9 4 4
2012-04-10protein level
9 4 4
2012-01-13protein level
9 4 4
2011-12-20protein level
9 3 4
2011-11-11protein level
9 2 2
2011-08-23protein level
9 2 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15350-1
0 24 0 69578.9915
NX_O15350-10
0 20 0 47794.0384
NX_O15350-11
0 22 0 61994.615
NX_O15350-12
1 16 0 38849.3359
NX_O15350-13
0 25 0 61655.4638
NX_O15350-2
0 18 0 54287.4
NX_O15350-3
0 20 0 52992.2113
NX_O15350-4
1 16 0 44488.7089
NX_O15350-5
0 25 0 61655.4638
NX_O15350-6
1 22 0 59849.3691
NX_O15350-8
0 24 0 64380.8186
NX_O15350-9
0 18 0 49089.2271
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-389606,EBI-448680 AURKA  
  .neuron projection extension
.positive regulation of oocyte maturation
.negative regulation of spindle checkpoint
  + 21 more...
.histone serine kinase activity
.protein kinase binding
.ATP binding
  + 3 more...
.meiotic spindle
.mitotic spindle
.spindle midzone
  + 14 more...
2 EBI-389606,EBI-354932 HSPA9  
  .cellular protein metabolic process
.negative regulation of apoptotic process
.protein targeting to mitochondrion
  + 2 more...
.unfolded protein binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
.ATP binding
.extracellular exosome
.mitochondrial nucleoid
.focal adhesion
  + 3 more...
3 EBI-389619,EBI-1044059 YAP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of stem cell differentiation
.negative regulation of nucleic acid-templated transcription
  + 24 more...
.transcription regulatory region DNA binding
.transcription corepressor activity
.transcription coactivator activity
  + 3 more...
.cell junction
.membrane
.cytosol
  + 4 more...
4 EBI-389606,EBI-976402 RUNX2  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.cellular response to BMP stimulus
.stem cell differentiation
  + 27 more...
.ATP binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 4 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
.nuclear chromatin
5 EBI-389606,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
6 EBI-389619,EBI-1564678 ITCH  
  .regulation of protein deubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 21 more...
.ubiquitin protein ligase activity
.CXCR chemokine receptor binding
.ribonucleoprotein complex binding
  + 2 more...
.extracellular exosome
.cytoplasmic vesicle
.membrane
  + 5 more...
7 EBI-389619,EBI-2339650 CASP8AP2  
  .negative regulation of nucleic acid-templated transcription
.apoptotic signaling pathway
.cellular response to mechanical stimulus
  + 7 more...
.SUMO polymer binding
.peptidase activator activity involved in apoptotic process
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 3 more...
.PML body
.mitochondrion
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain1
connective tissue13
embryonic tissue9
eye14
heart11
intestine12
liver4
lung8
lymph node55
mammary gland13
mouth120
muscle37
pancreas4
pharynx49
placenta10
prostate15
salivary gland49
stomach10
testis4
trachea77
uterus12
Health State
TissuesTPM*
normal6
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor8
germ cell tumor11
head and neck tumor67
liver tumor10
lung tumor19
non-neoplasia20
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
retinoblastoma43
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult8
embryoid body14
blastocyst16
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus1.3
lung1.1
lymph node1.1
prostate1.5
salivary gland2.2
skin6.5
Tissues
TissuesExpression level
bronchusHigh
esophagusMedium
fallopian tubeMedium
nasopharynxHigh
oral mucosaMedium
skin 1High
skin 2Medium
tonsilMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601990, gene) Tumor protein p73; TP73OMIM


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