Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O15360)
Protein (NX_O15360)
Protein
Gene SymbolFANCA to neXtProt (NX_O15360)
DescriptionFanconi anemia group A protein
Chromosome16
Location16q24.3 (89803957 ~ 89883065) to Ensembl
Sequene Features : Isoforms 3, Variants 241, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell proliferation
.female gonad development
.male gonad development
  + 3 more...
.N/A .Fanconi anaemia nuclear complex
.cytoplasm
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 241 9
2014-09-19protein level
3 214 9
2014-05-27protein level
3 213 9
2014-02-25protein level
2 209 9
2013-12-09protein level
2 154 9
2013-11-01protein level
2 150 9
2013-09-12protein level
2 150 9
2013-08-17protein level
2 152 9
2013-07-15protein level
2 121 1
2013-06-11protein level
2 121 1
2013-02-12protein level
2 95 4
2012-12-20protein level
2 97 4
2012-10-30protein level
2 106 4
2012-10-07protein level
2 106 4
2012-08-24protein level
2 97 4
2012-07-28protein level
2 97 4
2012-06-08protein level
2 97 4
2012-05-07protein level
2 97 4
2012-04-10protein level
2 97 4
2012-01-13protein level
2 71 4
2011-12-20protein level
2 71 4
2011-11-11protein level
2 71 4
2011-08-23protein level
2 71 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15360-1
5 64 0 162670.8948
NX_O15360-2
0 12 0 32962.7208
NX_O15360-3
1 64 0 158980.9586
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81570,EBI-81610 FANCG  
  .response to radiation
.spermatid development
.mitochondrion organization
  + 3 more...
.damaged DNA binding .Fanconi anaemia nuclear complex
.plasma membrane
.mitochondrion
  + 3 more...
2 EBI-81570,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-81570,EBI-2557990 FAAP100  
  .DNA repair .DNA binding .intermediate filament cytoskeleton
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
4 EBI-81570,EBI-81589 FANCF  
  .activation of mitophagy in response to mitochondrial depolarization
.spermatogenesis
.DNA repair
.ovarian follicle development
.ubiquitin-protein transferase activity .Fanconi anaemia nuclear complex
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder66
blood40
bone55
brain17
cervix288
embryonic tissue51
eye23
intestine90
kidney14
liver53
lung38
lymph270
lymph node144
mammary gland19
muscle18
ovary39
pancreas4
placenta28
prostate15
skin23
spleen18
stomach52
testis55
thymus25
thyroid21
umbilical cord217
uterus64
Health State
TissuesTPM*
normal27
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor173
chondrosarcoma48
colorectal tumor106
gastrointestinal tumor25
germ cell tumor45
glioma46
head and neck tumor7
kidney tumor43
leukemia21
liver tumor62
lung tumor97
lymphoma166
primitive neuroectodermal tumor of the CNS15
prostate cancer28
retinoblastoma86
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor88
Developmental Stage
TissuesTPM*
adult41
embryoid body42
blastocyst65
neonate96
fetus28
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.6
adrenal gland2.4
appendix17.2
bone marrow24.4
cerebral cortex2.9
colon8.3
duodenum10.8
esophagus3.5
gallbladder4.4
heart muscle1.4
kidney1.6
liver6
lung7.4
lymph node27.6
ovary1.4
pancreas1
placenta8.4
prostate2.9
salivary gland2.3
skin7.7
small intestine10.6
spleen8.8
stomach8.7
testis21.5
thyroid gland2
urinary bladder5.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#227650, phenotype) Fanconi anemia, complementation group a; FANCAOMIM
2(*607139, gene) Fanca gene; FANCAOMIM
3acute myelogenous leukemia;leukemia;Fanconi anaemia ACGP


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center