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> Protein (NX_O15371)
Protein (NX_O15371)
Protein
Gene SymbolEIF3D to neXtProt (NX_O15371)
DescriptionEukaryotic translation initiation factor 3 subunit D
Chromosome22
Location22q12.3 (36906897 ~ 36925483) to Ensembl
Sequene Features : Isoforms 3, Variants 40, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 4 more...
.poly(A) RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 3 complex, eIF3m
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 40 10
2014-09-19protein level
3 31 10
2014-05-27protein level
1 31 10
2014-02-25protein level
1 32 10
2013-12-09protein level
1 25 10
2013-11-01protein level
1 23 7
2013-09-12protein level
1 23 8
2013-08-17protein level
1 23 8
2013-07-15protein level
1 12 5
2013-06-11protein level
1 12 5
2013-02-12protein level
1 5 7
2012-12-20protein level
1 6 7
2012-10-30protein level
1 6 7
2012-10-07protein level
1 6 7
2012-08-24protein level
1 1 7
2012-07-28protein level
1 1 7
2012-06-08protein level
1 1 7
2012-05-07protein level
1 1 7
2012-04-10protein level
1 1 7
2012-01-13protein level
1 3 7
2011-12-20protein level
1 3 7
2011-11-11protein level
1 3 7
2011-08-23protein level
1 3 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15371-1
0 23 0 63932.2516
NX_O15371-2
0 22 0 58103.5474
NX_O15371-3
0 23 0 62000.2091
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-353818,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-353818,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-353818,EBI-724373 BEND5  
  .N/A .N/A .Golgi apparatus
4 EBI-353818,EBI-738731 PHLDA1  
  .FasL biosynthetic process
.positive regulation of apoptotic process
.forebrain neuron differentiation
.apoptotic process
.N/A .cytoplasmic vesicle membrane
.plasma membrane
.nucleolus
.nucleoplasm
5 EBI-353818,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland242
ascites878
bladder669
blood392
bone279
bone marrow164
brain262
cervix329
connective tissue295
ear124
embryonic tissue267
esophagus843
eye220
heart457
intestine426
kidney275
larynx255
liver214
lung316
lymph880
lymph node144
mammary gland363
mouth75
muscle338
nerve193
ovary226
pancreas145
parathyroid194
pharynx392
pituitary gland181
placenta314
prostate253
salivary gland98
skin417
spleen243
stomach553
testis255
thymus439
thyroid257
tonsil470
trachea154
umbilical cord435
uterus340
vascular387
Health State
TissuesTPM*
normal248
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor386
cervical tumor405
chondrosarcoma313
colorectal tumor453
esophageal tumor869
gastrointestinal tumor497
germ cell tumor372
glioma363
head and neck tumor186
kidney tumor217
leukemia359
liver tumor354
lung tumor515
lymphoma1121
non-neoplasia217
ovarian tumor196
pancreatic tumor219
primitive neuroectodermal tumor of the CNS1118
prostate cancer317
retinoblastoma409
skin tumor438
soft tissue/muscle tissue tumor351
uterine tumor377
Developmental Stage
TissuesTPM*
adult265
embryoid body285
blastocyst292
neonate386
fetus215
infant765
juvenile1403
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue86.5
adrenal gland83.9
appendix114.4
bone marrow131.6
cerebral cortex44.8
colon117.2
duodenum104.8
esophagus143.3
gallbladder105.3
heart muscle83.2
kidney79.8
liver43.1
lung85.2
lymph node184.8
ovary196.4
pancreas79.7
placenta109.7
prostate91.2
salivary gland106.4
skin120.2
small intestine102.1
spleen137.1
stomach100.1
testis70.1
thyroid gland135.8
urinary bladder144.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603915, gene) Eukaryotic translation initiation factor 3, subunit d; EIF3DOMIM


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