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> Protein (NX_O15379)
Protein (NX_O15379)
Protein
Gene SymbolHDAC3 to neXtProt (NX_O15379)
DescriptionHistone deacetylase 3
Chromosome5
Location5q31.3 (141000443 ~ 141016437) to Ensembl
Sequene Features : Isoforms 2, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to fluid shear stress
.spindle assembly
.neurotrophin TRK receptor signaling pathway
  + 21 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.transcriptional repressor complex
.plasma membrane
.spindle microtubule
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 37 3
2014-09-19protein level
2 24 3
2014-05-27protein level
2 24 3
2014-02-25protein level
2 24 3
2013-12-09protein level
2 22 3
2013-11-01protein level
2 21 3
2013-09-12protein level
2 21 3
2013-08-17protein level
2 21 3
2013-07-15protein level
2 11 2
2013-06-11protein level
2 11 2
2013-02-12protein level
2 7 4
2012-12-20protein level
2 7 4
2012-10-30protein level
2 8 4
2012-10-07protein level
2 8 2
2012-08-24protein level
2 2 2
2012-07-28protein level
2 2 2
2012-06-08protein level
2 2 2
2012-05-07protein level
2 2 2
2012-04-10protein level
2 2 2
2012-01-13protein level
2 2 2
2011-12-20protein level
2 4 2
2011-11-11protein level
2 4 2
2011-08-23protein level
2 4 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15379-1
1 21 1 48816.304
NX_O15379-2
1 22 1 49079.4381
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-607682,EBI-710124 KDM1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
2 EBI-607682,EBI-347233 NCOR1  
  .regulation of fatty acid transport
.regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
.regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
  + 22 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.histone deacetylase binding
  + 6 more...
.transcriptional repressor complex
.membrane
.spindle microtubule
  + 5 more...
3 EBI-607682,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
4 EBI-607682,EBI-5650739 MAGEA2B  
  .negative regulation of protein acetylation
.cellular senescence
.signal transduction by p53 class mediator
  + 5 more...
.repressing transcription factor binding
.histone deacetylase binding
.ubiquitin protein ligase binding
.PML body
.nucleus
5 EBI-607682,EBI-746484 NRIP1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.circadian regulation of gene expression
  + 6 more...
.androgen receptor binding
.glucocorticoid receptor binding
.nuclear hormone receptor binding
  + 4 more...
.cell junction
.nuclear speck
.nucleolus
  + 3 more...
6 EBI-607682,EBI-1046072 PPP4C  
  .NIK/NF-kappaB signaling
.dephosphorylation
.regulation of double-strand break repair via homologous recombination
.metal ion binding
.protein serine/threonine phosphatase activity
.NF-kappaB-inducing kinase activity
.protein phosphatase 4 complex
.plasma membrane
.microtubule organizing center
  + 3 more...
7 EBI-607682,EBI-1264675 SUZ12  
  .negative regulation of gene expression, epigenetic
.negative regulation of cell differentiation
.regulation of gene expression, epigenetic
  + 6 more...
.metal ion binding
.sequence-specific DNA binding
.histone methyltransferase activity
  + 3 more...
.ESC/E(Z) complex
.nucleolus
.nucleoplasm
  + 2 more...
8 EBI-607682,EBI-1211456 DHX30  
  .RNA processing .poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
  + 2 more...
.mitochondrial nucleoid
.mitochondrion
.cytoplasm
.nucleus
9 EBI-607682,EBI-739909 L3MBTL2  
  .chromatin modification
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.histone binding
.methylated histone binding
.zinc ion binding
.nucleus
10 EBI-607682,EBI-867196 MBD1  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.methyl-CpG binding
.zinc ion binding
.transcription corepressor activity
  + 2 more...
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
11 EBI-607682,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
12 EBI-607682,EBI-7216962 NR2E3  
  .retina development in camera-type eye
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of rhodopsin gene expression
  + 10 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
.steroid hormone receptor activity
.transcription factor complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder33
blood98
bone55
brain24
cervix144
connective tissue20
ear62
embryonic tissue108
eye47
heart33
intestine60
kidney33
liver38
lung83
lymph67
lymph node77
mammary gland33
muscle84
nerve64
ovary118
pancreas79
parathyroid48
placenta52
prostate42
skin85
spleen18
stomach73
testis32
thyroid64
tonsil176
uterus51
Health State
TissuesTPM*
normal47
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma96
colorectal tumor79
gastrointestinal tumor67
germ cell tumor34
glioma74
head and neck tumor22
kidney tumor43
leukemia105
liver tumor41
lung tumor97
lymphoma41
ovarian tumor65
pancreatic tumor95
primitive neuroectodermal tumor of the CNS118
prostate cancer48
retinoblastoma21
skin tumor143
soft tissue/muscle tissue tumor79
uterine tumor33
Developmental Stage
TissuesTPM*
adult56
embryoid body85
blastocyst146
fetus61
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.1
adrenal gland47.3
appendix36
bone marrow45.7
cerebral cortex25
colon31.6
duodenum29.4
esophagus35.2
gallbladder33
heart muscle25.3
kidney26.4
liver24.7
lung34.3
lymph node51.8
ovary43.3
pancreas18.7
placenta33.4
prostate30.5
salivary gland25.4
skin46.9
small intestine27.6
spleen35.9
stomach27.2
testis28.4
thyroid gland39
urinary bladder34.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusLow
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungLow
lymph nodeMedium
nasopharynxLow
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605166, gene) Histone deacetylase 3; HDAC3OMIM


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