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> Protein (NX_O15409)
Protein (NX_O15409)
Protein
Gene SymbolFOXP2 to neXtProt (NX_O15409)
DescriptionForkhead box protein P2
Chromosome7
Location7q31.1 (113726382 ~ 114333827) to Ensembl
Sequene Features : Isoforms 8, Variants 129, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of epithelial cell proliferation involved in lung morphogenesis
.righting reflex
.smooth muscle tissue development
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 4 more...
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 129 1
2014-09-19protein level
8 92 1
2014-05-27protein level
8 91 1
2014-02-25protein level
8 90 1
2013-12-09protein level
8 80 1
2013-11-01protein level
8 75 1
2013-09-12protein level
8 75 1
2013-08-17protein level
8 75 1
2013-07-15protein level
8 41 1
2013-06-11protein level
8 41 1
2013-02-12protein level
8 11 4
2012-12-20protein level
8 11 4
2012-10-30protein level
8 17 4
2012-10-07protein level
8 17 1
2012-08-24protein level
8 17 1
2012-07-28protein level
8 17 1
2012-06-08protein level
8 24 1
2012-05-07protein level
8 13 1
2012-04-10protein level
7 13 1
2012-01-13protein level
7 7 1
2011-12-20protein level
7 7 1
2011-11-11protein level
7 7 0
2011-08-23protein level
7 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15409-1
0 25 0 79869.5679
NX_O15409-2
1 21 0 70060.7574
NX_O15409-4
1 25 0 82513.7769
NX_O15409-5
1 4 0 18303.0018
NX_O15409-6
1 14 0 48734.0282
NX_O15409-7
0 12 0 40944.166
NX_O15409-8
0 3 0 9371.548
NX_O15409-9
2 24 0 81789.5003
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-983612,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-983612,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
3 EBI-983612,EBI-741533 CTBP2  
  .white fat cell differentiation
.positive regulation of retinoic acid receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.NAD binding
.oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
.transcription corepressor activity
  + 2 more...
.synapse
.cell junction
.transcriptional repressor complex
.nucleus
4 EBI-983612,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
5 EBI-983612,EBI-10171858 CTBP1  
  .negative regulation of transcription from RNA polymerase II promoter by histone modification
.negative regulation of histone H4 acetylation
.regulation of cell cycle
  + 9 more...
.repressing transcription factor binding
.NAD binding
.protein domain specific binding
  + 5 more...
.transcriptional repressor complex
.cytosol
.transcription factor complex
  + 2 more...
6 EBI-983612,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
7 EBI-983612,EBI-744506 FAM124A  
  .N/A .N/A .N/A
8 EBI-983612,EBI-740411 TSACC  
  .N/A .chaperone binding .cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bone13
bone marrow20
brain12
cervix20
ear496
embryonic tissue4
eye14
intestine12
kidney9
liver29
lung14
mammary gland19
mouth75
muscle18
nerve64
prostate15
skin14
spleen18
testis6
thyroid21
trachea38
uterus30
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor8
head and neck tumor37
leukemia10
liver tumor10
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult12
fetus41
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.7
adrenal gland3.4
appendix2.5
cerebral cortex5.3
colon8.4
duodenum3.4
esophagus13.6
gallbladder7.7
heart muscle1.7
kidney2.3
liver3.4
lung4.3
ovary24.4
pancreas5.1
placenta1.4
prostate2.3
salivary gland4.4
skin4.9
small intestine4.9
stomach1.6
testis2.5
thyroid gland12.4
urinary bladder8.2
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#602081, phenotype) Speech-language disorder 1; SPCH1OMIM
2(*605317, gene) Forkhead box p2; FOXP2OMIM


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