Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O15455)
Protein (NX_O15455)
Protein
Gene SymbolTLR3 to neXtProt (NX_O15455)
DescriptionToll-like receptor 3
Chromosome4
Location4q35.1 (186990306 ~ 187009223) to Ensembl
Sequene Features : Isoforms 2, Variants 111, PTMs 21 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.necroptotic signaling pathway
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 43 more...
.identical protein binding
.transmembrane signaling receptor activity
.receptor activity
.double-stranded RNA binding
.endolysosome membrane
.membrane
.endosome membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 111 21
2014-09-19protein level
2 82 21
2014-05-27protein level
2 82 21
2014-02-25protein level
1 81 21
2013-12-09protein level
1 65 21
2013-11-01protein level
1 62 21
2013-09-12protein level
1 62 21
2013-08-17protein level
1 62 21
2013-07-15protein level
1 41 21
2013-06-11protein level
1 41 21
2013-02-12protein level
1 27 21
2012-12-20protein level
1 26 21
2012-10-30protein level
1 30 21
2012-10-07protein level
1 30 21
2012-08-24protein level
1 28 21
2012-07-28protein level
1 28 21
2012-06-08protein level
1 39 21
2012-05-07protein level
1 29 21
2012-04-10protein level
1 29 21
2012-01-13protein level
1 23 21
2011-12-20protein level
1 23 21
2011-11-11protein level
1 23 21
2011-08-23protein level
1 23 21
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15455-1
17 29 0 103762.4684
NX_O15455-2
1 29 0 72890.4835
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6116630,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
bone13
brain7
connective tissue13
eye9
intestine8
kidney18
liver4
lung2
mammary gland13
mouth15
muscle18
pancreas14
placenta91
skin4
spleen37
stomach20
testis11
thymus12
trachea193
uterus4
Health State
TissuesTPM*
normal17
adrenal tumor79
gastrointestinal tumor16
germ cell tumor3
glioma9
head and neck tumor7
non-neoplasia20
Developmental Stage
TissuesTPM*
adult18
fetus1
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.5
adrenal gland6
appendix3.7
cerebral cortex2.8
colon11.9
duodenum17
esophagus9.2
gallbladder12.6
heart muscle2.7
kidney8.9
liver7.5
lung10
lymph node1.1
ovary8.8
pancreas2.7
placenta25
prostate5.8
salivary gland7.5
skin3.7
small intestine15.8
spleen5.7
stomach11.6
testis6.2
thyroid gland8.2
urinary bladder14.4
Tissues
TissuesExpression level
adrenal glandMedium
breastLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
kidneyMedium
liverMedium
lungMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateLow
rectumLow
seminal vesicleLow
skin 1Low
skin 2Low
small intestineMedium
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603029, gene) Toll-like receptor 3; TLR3OMIM
2(#613002, phenotype) Herpes simplex encephalitis, susceptibility to, 2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center