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> Protein (NX_O15519)
Protein (NX_O15519)
Protein
Gene SymbolCFLAR to neXtProt (NX_O15519)
DescriptionCASP8 and FADD-like apoptosis regulator
Chromosome2
Location2q33.1 (201980827 ~ 202041410) to Ensembl
Sequene Features : Isoforms 15, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 20 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.death effector domain binding
.enzyme activator activity
.protease binding
.ripoptosome
.membrane raft
.CD95 death-inducing signaling complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
15 35 1
2014-09-19protein level
15 27 1
2014-05-27protein level
15 27 1
2014-02-25protein level
15 27 1
2013-12-09protein level
15 22 1
2013-11-01protein level
15 21 0
2013-09-12protein level
15 21 0
2013-08-17protein level
15 21 0
2013-07-15protein level
15 17 0
2013-06-11protein level
15 17 0
2013-02-12protein level
15 9 0
2012-12-20protein level
15 12 0
2012-10-30protein level
15 13 0
2012-10-07protein level
15 13 0
2012-08-24protein level
14 13 0
2012-07-28protein level
14 13 0
2012-06-08protein level
14 10 0
2012-05-07protein level
14 10 0
2012-04-10protein level
14 10 0
2012-01-13protein level
14 10 0
2011-12-20protein level
14 10 0
2011-11-11protein level
14 10 0
2011-08-23protein level
14 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15519-1
0 24 0 55308.5063
NX_O15519-10
2 14 0 34362.0045
NX_O15519-11
0 24 0 52516.9265
NX_O15519-12
1 14 0 33251.6052
NX_O15519-13
0 12 0 23274.4596
NX_O15519-14
0 22 0 49745.5468
NX_O15519-15
0 18 0 44083.4469
NX_O15519-2
1 12 0 25362.4205
NX_O15519-3
0 18 0 41291.8671
NX_O15519-4
0 10 0 27037.4343
NX_O15519-5
1 22 0 51357.4879
NX_O15519-6
3 19 0 50628.0529
NX_O15519-7
0 17 0 39219.7385
NX_O15519-8
0 22 0 51296.394
NX_O15519-9
2 12 0 30379.876
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-4567563,EBI-492605 MAP2K7  
  .cellular response to sorbitol
.stress-activated MAPK cascade
.innate immune response
  + 22 more...
.protein phosphatase binding
.protein kinase binding
.enzyme binding
  + 6 more...
.cytosol
.cytoplasm
.nucleus
.intracellular
2 EBI-4567563,EBI-492564 MAP2K1  
  .regulation of early endosome to late endosome transport
.activation of mitophagy in response to mitochondrial depolarization
.cellular senescence
  + 55 more...
.protein N-terminus binding
.protein serine/threonine kinase activator activity
.protein C-terminus binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.perikaryon
  + 15 more...
3 EBI-514941,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
4 EBI-514941,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
5 EBI-514941,EBI-495095 CASP10  
  .apoptotic signaling pathway
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 3 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.death effector domain binding
.ubiquitin protein ligase binding
.cysteine-type endopeptidase activity
.ripoptosome
.CD95 death-inducing signaling complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites25
bladder66
blood220
bone27
bone marrow61
brain50
cervix20
connective tissue40
embryonic tissue14
esophagus49
eye14
heart78
intestine133
kidney56
larynx340
liver102
lung140
lymph338
lymph node33
mammary gland119
mouth105
muscle28
nerve64
ovary19
pancreas74
pharynx122
placenta70
prostate52
salivary gland49
skin42
spleen149
stomach188
testis9
thymus62
thyroid257
tonsil58
trachea19
umbilical cord72
uterus86
vascular58
Health State
TissuesTPM*
normal32
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma60
colorectal tumor35
esophageal tumor57
gastrointestinal tumor25
germ cell tumor18
glioma27
head and neck tumor67
kidney tumor29
leukemia21
liver tumor62
lung tumor9
lymphoma13
non-neoplasia31
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS47
prostate cancer28
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor77
Developmental Stage
TissuesTPM*
adult20
embryoid body14
blastocyst16
neonate160
fetus21
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue93.5
adrenal gland46.7
appendix100.3
bone marrow126
cerebral cortex16.1
colon49.6
duodenum48.8
esophagus59.8
gallbladder63.9
heart muscle83.9
kidney48.4
liver34.1
lung88.3
lymph node84.2
ovary23.5
pancreas17.5
placenta65.7
prostate42.4
salivary gland36
skin28
small intestine53
spleen81.2
stomach48.9
testis26.3
thyroid gland48.1
urinary bladder56.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603599, gene) Casp8- and fadd-like apoptosis regulator; CFLAROMIM


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