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> Protein (NX_O15524)
Protein (NX_O15524)
Protein
Gene SymbolSOCS1 to neXtProt (NX_O15524)
DescriptionSuppressor of cytokine signaling 1
Chromosome16
Location16p13.13 (11348262 ~ 11350036) to Ensembl
Sequene Features : Isoforms 1, Variants 40, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to amino acid stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.regulation of type I interferon-mediated signaling pathway
  + 13 more...
.protein kinase binding
.kinase inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase inhibitor activity
.cytoplasmic membrane-bounded vesicle
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 40 0
2014-09-19protein level
1 35 0
2014-05-27protein level
1 35 0
2014-02-25protein level
1 35 0
2013-12-09protein level
1 34 0
2013-11-01protein level
1 34 0
2013-09-12protein level
1 34 0
2013-08-17protein level
1 34 0
2013-07-15protein level
1 31 0
2013-06-11protein level
1 31 0
2013-02-12protein level
1 24 0
2012-12-20protein level
1 24 0
2012-10-30protein level
1 24 0
2012-10-07protein level
1 24 0
2012-08-24protein level
1 10 0
2012-07-28protein level
1 10 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 6 0
2011-12-20protein level
1 6 0
2011-11-11protein level
1 6 0
2011-08-23protein level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15524-1
10 0 0 23536.0528
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-968198,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-968198,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
3 EBI-968198,EBI-301231 TCEB1  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.positive regulation of viral transcription
  + 7 more...
.N/A .elongin complex
.cytosol
.nucleoplasm
4 EBI-968198,EBI-1550112 COMMD1  
  .negative regulation of protein localization to cell surface
.negative regulation of sodium ion transmembrane transport
.copper ion homeostasis
  + 7 more...
.phosphatidylinositol-3,5-bisphosphate binding
.phosphatidic acid binding
.phosphatidylinositol-3,4-bisphosphate binding
  + 5 more...
.extracellular exosome
.recycling endosome
.Cul2-RING ubiquitin ligase complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain7
cervix20
eye9
heart145
intestine38
kidney42
lung77
lymph67
lymph node233
muscle18
ovary275
pancreas51
pharynx24
placenta28
prostate15
skin9
spleen18
testis4
thymus12
thyroid21
uterus4
Health State
TissuesTPM*
normal31
chondrosarcoma12
colorectal tumor53
germ cell tumor56
glioma65
head and neck tumor7
leukemia31
lung tumor9
lymphoma41
non-neoplasia41
ovarian tumor367
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult34
fetus77
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.7
adrenal gland1.2
appendix10.4
bone marrow5.4
colon3.6
duodenum1.4
esophagus2.2
gallbladder2.6
kidney3.2
liver1.1
lung2.4
lymph node10.5
ovary2.6
placenta3.3
prostate3.9
salivary gland1.7
small intestine3
spleen6
stomach4.5
testis2.2
thyroid gland1
urinary bladder1.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603597, gene) Suppressor of cytokine signaling 1; SOCS1OMIM
2Hodgkin Lymphoma;primary mediastinal B-cell lymphomaCGP


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