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> Protein (NX_O15530)
Protein (NX_O15530)
Protein
Gene SymbolPDPK1 to neXtProt (NX_O15530)
Description3-phosphoinositide-dependent protein kinase 1
Chromosome16
Location16p13.3 (2587965 ~ 2653189) to Ensembl
Sequene Features : Isoforms 5, Variants 31, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.extrinsic apoptotic signaling pathway
.positive regulation of establishment of protein localization to plasma membrane
.cellular response to epidermal growth factor stimulus
  + 38 more...
.phospholipase binding
.kinase activity
.phospholipase activator activity
  + 3 more...
.cell projection
.cytoplasmic membrane-bounded vesicle
.focal adhesion
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 31 16
2014-09-19protein level
5 21 16
2014-05-27protein level
5 20 19
2014-02-25protein level
5 20 19
2013-12-09protein level
5 16 19
2013-11-01protein level
5 14 17
2013-09-12protein level
5 14 17
2013-08-17protein level
5 14 17
2013-07-15protein level
5 5 15
2013-06-11protein level
5 5 15
2013-02-12protein level
5 3 81
2012-12-20protein level
5 3 81
2012-10-30protein level
4 7 66
2012-10-07protein level
4 7 18
2012-08-24protein level
4 7 18
2012-07-28protein level
4 7 18
2012-06-08protein level
4 18 15
2012-05-07protein level
4 15 15
2012-04-10protein level
4 15 15
2012-01-13protein level
4 19 15
2011-12-20protein level
4 18 12
2011-11-11protein level
4 18 13
2011-08-23protein level
3 18 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15530-1
0 25 0 63111.8033
NX_O15530-2
1 22 0 57998.3448
NX_O15530-3
1 23 0 60357.4464
NX_O15530-4
0 19 0 48169.9811
NX_O15530-5
1 19 0 50805.4721
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717097,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
2 EBI-717097,EBI-1052159 PPP2R2B  
  .regulation of protein phosphatase type 2A activity
.signal transduction
.apoptotic process
.protein phosphatase type 2A regulator activity .cytoskeleton
.mitochondrial outer membrane
.mitochondrion
.protein phosphatase type 2A complex
3 EBI-9087775,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder33
blood65
bone27
bone marrow41
brain96
cervix41
connective tissue13
ear62
embryonic tissue70
esophagus49
eye95
heart44
intestine150
kidney85
liver73
lung83
lymph45
lymph node122
mammary gland39
mouth120
muscle47
ovary29
pancreas74
pharynx24
pituitary gland60
placenta81
prostate63
skin66
spleen18
stomach94
testis98
thymus87
thyroid150
trachea135
uterus73
vascular19
Health State
TissuesTPM*
normal80
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor57
colorectal tumor186
esophageal tumor57
gastrointestinal tumor59
germ cell tumor121
glioma121
head and neck tumor97
kidney tumor58
leukemia84
liver tumor83
lung tumor58
lymphoma27
non-neoplasia72
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS86
prostate cancer67
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult84
embryoid body85
blastocyst81
neonate64
fetus73
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.4
adrenal gland20.1
appendix18.3
bone marrow13.4
cerebral cortex28
colon23.6
duodenum23.2
esophagus19.6
gallbladder15.6
heart muscle19
kidney27.1
liver6.7
lung19.9
lymph node23.2
ovary22.9
pancreas12.2
placenta20.3
prostate19.8
salivary gland20.1
skin23.4
small intestine24.9
spleen18.7
stomach17
testis22.7
thyroid gland26.8
urinary bladder19.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605213, gene) 3-@phosphoinositide-dependent protein kinase 1; PDPK1OMIM


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