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> Protein (NX_O15553)
Protein (NX_O15553)
Protein
Gene SymbolMEFV to neXtProt (NX_O15553)
DescriptionPyrin
Chromosome16
Location16p13.3 (3292028 ~ 3306627) to Ensembl
Sequene Features : Isoforms 3, Variants 228, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cysteine-type endopeptidase activity
.negative regulation of macrophage inflammatory protein 1 alpha production
.negative regulation of inflammatory response
  + 5 more...
.zinc ion binding
.actin binding
.lamellipodium
.microtubule associated complex
.microtubule
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 228 0
2014-09-19protein level
3 184 0
2014-05-27protein level
3 184 0
2014-02-25protein level
3 179 0
2013-12-09protein level
3 158 0
2013-11-01protein level
3 150 0
2013-09-12protein level
3 150 0
2013-08-17protein level
3 150 0
2013-07-15protein level
2 119 0
2013-06-11protein level
2 119 0
2013-02-12protein level
2 95 0
2012-12-20protein level
2 86 0
2012-10-30protein level
2 94 0
2012-10-07protein level
2 94 0
2012-08-24protein level
2 83 0
2012-07-28protein level
2 84 0
2012-06-08protein level
2 84 0
2012-05-07protein level
2 83 0
2012-04-10protein level
2 83 0
2012-01-13protein level
2 112 0
2011-12-20protein level
2 112 0
2011-11-11protein level
2 112 0
2011-08-23protein level
2 112 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O15553-1
0 24 0 64452.7663
NX_O15553-2
13 23 0 86389.7313
NX_O15553-3
3 14 0 50804.4757
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood49
testis4
Health State
TissuesTPM*
normal1
leukemia21
Developmental Stage
TissuesTPM*
adult1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.3
appendix8.6
bone marrow4.1
gallbladder1.5
lung2.1
spleen7
testis1.3
urinary bladder1.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#134610, phenotype) Familial mediterranean fever, autosomal dominantOMIM
2(#249100, phenotype) Familial mediterranean fever; FMFOMIM
3(*608107, gene) Familial mediterranean fever gene; MEFVOMIM


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