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> Protein (NX_O43150)
Protein (NX_O43150)
Protein
Gene SymbolASAP2 to neXtProt (NX_O43150)
DescriptionArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Chromosome2
Location2p25.1 (9346894 ~ 9545812) to Ensembl
Sequene Features : Isoforms 2, Variants 122, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of catalytic activity .zinc ion binding
.enzyme activator activity
.GTPase activator activity
.Golgi cisterna membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 122 3
2014-09-19protein level
2 85 3
2014-05-27protein level
2 85 3
2014-02-25protein level
2 84 3
2013-12-09protein level
2 66 3
2013-11-01protein level
2 62 3
2013-09-12protein level
2 62 3
2013-08-17protein level
2 62 3
2013-07-15protein level
2 41 3
2013-06-11protein level
2 41 3
2013-02-12protein level
2 18 5
2012-12-20protein level
2 18 5
2012-10-30protein level
2 16 5
2012-10-07protein level
2 16 3
2012-08-24protein level
2 14 3
2012-07-28protein level
2 14 3
2012-06-08protein level
2 16 3
2012-05-07protein level
2 11 3
2012-04-10protein level
2 11 3
2012-01-13protein level
2 7 3
2011-12-20protein level
2 7 3
2011-11-11protein level
2 7 3
2011-08-23protein level
2 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43150-1
4 40 1 111580.2713
NX_O43150-2
1 40 1 106914.8839
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-310968,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-310968,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
3 EBI-310968,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bone13
brain25
connective tissue20
embryonic tissue56
esophagus49
eye9
heart11
intestine56
kidney47
larynx85
liver43
lung14
lymph node11
mammary gland66
mouth120
muscle18
nerve64
ovary19
pancreas37
pituitary gland60
placenta10
skin47
stomach438
testis80
thymus12
trachea19
uterus30
vascular58
Health State
TissuesTPM*
normal33
bladder carcinoma56
breast (mammary gland) tumor64
chondrosarcoma36
colorectal tumor53
esophageal tumor57
gastrointestinal tumor320
germ cell tumor11
glioma18
head and neck tumor74
kidney tumor14
liver tumor62
non-neoplasia31
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS31
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult52
embryoid body114
fetus35
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.1
adrenal gland3.5
appendix5.7
cerebral cortex10.2
colon16.6
duodenum11.6
esophagus8.3
gallbladder11.8
heart muscle7.7
kidney21.2
liver1.9
lung10.6
lymph node3
ovary7.6
pancreas3.2
placenta8.6
prostate5.2
salivary gland4.5
skin13.5
small intestine12.6
spleen1.4
stomach23.2
testis41.3
thyroid gland18.9
urinary bladder9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603817, gene) Development- and differentiation-enhancing factor 2; DDEF2OMIM


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