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> Protein (NX_O43167)
Protein (NX_O43167)
Protein
Gene SymbolZBTB24 to neXtProt (NX_O43167)
DescriptionZinc finger and BTB domain-containing protein 24
Chromosome6
Location6q21 (109783797 ~ 109804440) to Ensembl
Sequene Features : Isoforms 2, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 67 0
2014-09-19protein level
2 56 0
2014-05-27protein level
2 56 0
2014-02-25protein level
2 57 0
2013-12-09protein level
2 46 0
2013-11-01protein level
2 45 0
2013-09-12protein level
2 45 0
2013-08-17protein level
2 45 0
2013-07-15protein level
2 31 0
2013-06-11protein level
2 31 0
2013-02-12protein level
2 20 0
2012-12-20protein level
2 18 0
2012-10-30protein level
2 20 0
2012-10-07protein level
2 20 0
2012-08-24protein level
2 14 0
2012-07-28protein level
2 14 0
2012-06-08protein level
2 3 0
2012-05-07protein level
2 3 0
2012-04-10protein level
2 3 0
2012-01-13protein level
2 3 0
2011-12-20protein level
2 4 0
2011-11-11protein level
2 4 0
2011-08-23protein level
2 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43167-1
15 15 1 78232.601
NX_O43167-2
2 15 0 37596.6615
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744471,EBI-740718 ZBTB43  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-744471,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
3 EBI-744471,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
4 EBI-744471,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
5 EBI-744471,EBI-9250559 CDA  
  .nucleobase-containing small molecule metabolic process
.protein homotetramerization
.negative regulation of nucleotide metabolic process
  + 8 more...
.protein homodimerization activity
.zinc ion binding
.cytidine deaminase activity
.nucleoside binding
.cytosol
.extracellular region
6 EBI-744471,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
7 EBI-744471,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
8 EBI-744471,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
9 EBI-744471,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
10 EBI-744471,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
11 EBI-744471,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
12 EBI-744471,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
13 EBI-744471,EBI-1389308 POGZ  
  .kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
14 EBI-744471,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
15 EBI-744471,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
16 EBI-744471,EBI-742887 CEP76  
  .regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
17 EBI-744471,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
18 EBI-744471,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
19 EBI-744471,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
20 EBI-744471,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
21 EBI-744471,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
22 EBI-744471,EBI-10183342 BCL11A  
  .negative regulation of dendrite development
.regulation of dendrite development
.positive regulation of collateral sprouting
  + 10 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
23 EBI-744471,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
24 EBI-744471,EBI-2796400 KLF15  
  .negative regulation of peptidyl-lysine acetylation
.cellular response to peptide
.glomerular visceral epithelial cell differentiation
  + 4 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
25 EBI-744471,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
26 EBI-744471,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
27 EBI-744471,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder66
blood8
bone41
brain11
cervix41
connective tissue6
embryonic tissue18
eye28
heart11
intestine8
kidney23
liver4
lung2
lymph node22
mammary gland46
muscle9
pancreas4
placenta7
prostate10
skin23
stomach31
testis9
uterus17
Health State
TissuesTPM*
normal13
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor57
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor8
germ cell tumor22
kidney tumor14
leukemia21
liver tumor10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma21
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult13
embryoid body14
blastocyst48
fetus16
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.5
adrenal gland2.5
appendix5.8
bone marrow5.1
cerebral cortex3.8
colon3.7
duodenum3.4
esophagus3.2
gallbladder2.9
heart muscle1.8
kidney3.7
liver1.5
lung3.9
lymph node8.7
ovary3.3
pancreas1.6
placenta3.8
prostate3.9
salivary gland3.2
skin4.1
small intestine3.4
spleen5.3
stomach3.9
testis4.9
thyroid gland5.3
urinary bladder4.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614064, gene) Zinc finger- and btb domain-containing protein 24; ZBTB24OMIM
2(#614069, phenotype) Immunodeficiency-centromeric instability-facial anomalies syndromeOMIM


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