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> Protein (NX_O43189)
Protein (NX_O43189)
Protein
Gene SymbolPHF1 to neXtProt (NX_O43189)
DescriptionPHD finger protein 1
Chromosome6
Location6p21.32 (33378176 ~ 33384230) to Ensembl
Sequene Features : Isoforms 2, Variants 62, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of histone H3-K27 methylation
.negative regulation of histone H3-K27 methylation
.negative regulation of gene expression, epigenetic
  + 5 more...
.methylated histone binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.site of double-strand break
.microtubule organizing center
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 62 3
2014-09-19protein level
2 50 3
2014-05-27protein level
2 47 3
2014-02-25protein level
2 20 3
2013-12-09protein level
2 5 3
2013-11-01protein level
2 5 2
2013-09-12protein level
2 5 2
2013-08-17protein level
2 5 2
2013-07-15protein level
2 5 2
2013-06-11protein level
2 5 2
2013-02-12protein level
2 5 2
2012-12-20protein level
2 5 2
2012-10-30protein level
2 8 2
2012-10-07protein level
2 8 2
2012-08-24protein level
2 8 2
2012-07-28protein level
2 8 2
2012-06-08protein level
2 9 2
2012-05-07protein level
2 9 2
2012-04-10protein level
2 5 2
2012-01-13protein level
2 5 2
2011-12-20protein level
2 5 2
2011-11-11protein level
2 6 2
2011-08-23protein level
2 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43189-1
13 18 0 62065.9957
NX_O43189-2
4 18 0 49610.543
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-530034,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
2 EBI-530034,EBI-2107455 VAC14  
  .small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
3 EBI-530034,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
4 EBI-530034,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
5 EBI-530034,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
6 EBI-530034,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
7 EBI-530034,EBI-517623 BIRC7  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.regulation of natural killer cell apoptotic process
.negative regulation of apoptotic process
  + 4 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.enzyme binding
.ligase activity
  + 3 more...
.Golgi apparatus
.cytoplasm
.nucleus
8 EBI-530034,EBI-742664 HSD17B14  
  .steroid catabolic process .testosterone 17-beta-dehydrogenase (NADP+) activity
.estradiol 17-beta-dehydrogenase activity
.cytosol
9 EBI-530034,EBI-350517 PDLIM7  
  .positive regulation of osteoblast differentiation
.cell differentiation
.actin cytoskeleton organization
  + 3 more...
.zinc ion binding .actin cytoskeleton
.focal adhesion
.cytoplasm
  + 3 more...
10 EBI-530034,EBI-310660 ATXN7L1  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood49
bone69
brain47
cervix20
connective tissue67
embryonic tissue37
esophagus49
eye62
heart22
intestine30
kidney28
liver14
lung53
lymph node55
mammary gland6
mouth45
muscle18
nerve128
ovary98
pancreas79
placenta49
prostate116
skin37
spleen74
stomach62
testis124
thymus100
thyroid21
tonsil58
trachea38
uterus68
vascular19
Health State
TissuesTPM*
normal50
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma96
colorectal tumor26
esophageal tumor57
gastrointestinal tumor33
germ cell tumor102
glioma102
head and neck tumor14
kidney tumor29
leukemia31
liver tumor20
lung tumor77
lymphoma13
non-neoplasia62
ovarian tumor39
pancreatic tumor104
primitive neuroectodermal tumor of the CNS31
prostate cancer48
retinoblastoma64
skin tumor47
soft tissue/muscle tissue tumor63
uterine tumor77
Developmental Stage
TissuesTPM*
adult61
embryoid body57
blastocyst16
neonate64
fetus41
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.9
adrenal gland55.7
appendix41.5
bone marrow80.7
cerebral cortex33.7
colon26.2
duodenum30.5
esophagus29.2
gallbladder57.1
heart muscle54.4
kidney42.5
liver16.4
lung56.4
lymph node63.8
ovary124.2
pancreas30.3
placenta33.7
prostate57.7
salivary gland58.7
skin29.8
small intestine32.6
spleen64.9
stomach32
testis102.8
thyroid gland68.5
urinary bladder42.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602881, gene) Phd finger protein 1; PHF1OMIM


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