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> Protein (NX_O43251)
Protein (NX_O43251)
Protein
Gene SymbolRBFOX2 to neXtProt (NX_O43251)
DescriptionRNA binding protein fox-1 homolog 2
Chromosome22
Location22q12.3 (36134783 ~ 36424473) to Ensembl
Sequene Features : Isoforms 10, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
10 48 4
2014-09-19protein level
10 37 4
2014-05-27protein level
10 34 5
2014-02-25protein level
10 34 2
2013-12-09protein level
10 29 2
2013-11-01protein level
10 28 1
2013-09-12protein level
10 28 1
2013-08-17protein level
10 28 1
2013-07-15protein level
10 16 1
2013-06-11protein level
10 16 1
2013-02-12protein level
10 7 0
2012-12-20protein level
10 7 0
2012-10-30protein level
10 5 0
2012-10-07protein level
10 5 0
2012-08-24protein level
10 3 0
2012-07-28protein level
10 3 0
2012-06-08protein level
10 5 0
2012-05-07protein level
10 5 0
2012-04-10protein level
10 5 0
2012-01-13protein level
10 5 0
2011-12-20protein level
10 6 0
2011-11-11protein level
10 6 0
2011-08-23protein level
10 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43251-1
0 8 6 41348.2359
NX_O43251-10
0 7 6 40325.8576
NX_O43251-2
0 7 6 40453.9158
NX_O43251-3
1 7 3 37855.5064
NX_O43251-4
0 6 6 39757.8966
NX_O43251-5
0 7 6 39929.6215
NX_O43251-6
0 10 6 47186.0541
NX_O43251-7
2 6 6 43152.2967
NX_O43251-8
1 9 6 47314.1123
NX_O43251-9
0 6 6 39489.7187
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746056,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
2 EBI-746056,EBI-373337 RNF8  
  .protein K48-linked ubiquitination
.histone H2A K63-linked ubiquitination
.protein K63-linked ubiquitination
  + 16 more...
.protein homodimerization activity
.histone binding
.ubiquitin protein ligase binding
  + 4 more...
.site of double-strand break
.midbody
.nucleolus
  + 3 more...
3 EBI-746056,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
4 EBI-746056,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
5 EBI-746056,EBI-352986 HNRNPF  
  .regulation of RNA splicing
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.single-stranded RNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
6 EBI-746056,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
7 EBI-746056,EBI-2107455 VAC14  
  .small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
8 EBI-746056,EBI-1058722 CAMK2B  
  .positive regulation of apoptotic signaling pathway
.regulation of cellular response to heat
.positive regulation of synapse maturation
  + 22 more...
.protein homodimerization activity
.ATP binding
.calmodulin-dependent protein kinase activity
.spindle midzone
.sarcoplasmic reticulum membrane
.endocytic vesicle membrane
  + 4 more...
9 EBI-746056,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
10 EBI-746056,EBI-946029 C1orf94  
  .N/A .N/A .N/A
11 EBI-746056,EBI-998198 BOLL  
  .positive regulation of translational initiation
.cell differentiation
.spermatogenesis
  + 2 more...
.translation activator activity
.RNA binding
.nucleotide binding
.cytoplasm
12 EBI-746056,EBI-741424 MAPK1IP1L  
  .N/A .N/A .N/A
13 EBI-746056,EBI-2515597 NAF1  
  .ribosome biogenesis
.rRNA processing
.pseudouridine synthesis
.poly(A) RNA binding
.RNA binding
.cytoplasm
.small nucleolar ribonucleoprotein complex
.nucleus
14 EBI-746056,EBI-945792 QKI  
  .3'-UTR-mediated mRNA destabilization
.mRNA transport
.long-chain fatty acid biosynthetic process
  + 8 more...
.poly(A) RNA binding
.mRNA binding
.cytoplasm
.nucleus
15 EBI-746056,EBI-945906 RBFOX1  
  .neuromuscular process controlling balance
.RNA transport
.regulation of RNA splicing
  + 2 more...
.protein C-terminus binding
.RNA binding
.nucleotide binding
.trans-Golgi network
.cytoplasm
.nucleus
16 EBI-746056,EBI-716006 MAGED1  
  .positive regulation of apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
  + 15 more...
.transcription coactivator activity .protein complex
.plasma membrane
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites125
bone111
bone marrow41
brain183
cervix123
connective tissue167
ear186
embryonic tissue220
eye134
heart201
intestine112
kidney47
liver29
lung137
lymph node55
mammary gland46
mouth45
muscle112
nerve128
ovary147
pancreas51
parathyroid242
pharynx73
pituitary gland121
placenta70
prostate94
salivary gland98
skin104
spleen131
stomach52
testis59
thymus12
thyroid150
trachea77
uterus103
vascular116
Health State
TissuesTPM*
normal141
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor64
cervical tumor144
chondrosarcoma205
colorectal tumor79
gastrointestinal tumor84
germ cell tumor102
glioma65
head and neck tumor82
kidney tumor58
liver tumor41
lung tumor9
lymphoma13
non-neoplasia62
ovarian tumor157
pancreatic tumor76
primitive neuroectodermal tumor of the CNS157
prostate cancer57
retinoblastoma86
skin tumor63
soft tissue/muscle tissue tumor143
uterine tumor66
Developmental Stage
TissuesTPM*
adult97
embryoid body214
blastocyst179
neonate32
fetus317
infant212
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.3
adrenal gland25.9
appendix20.5
cerebral cortex46.3
colon27.9
duodenum17.2
esophagus48.2
gallbladder42.5
heart muscle44.7
kidney20.2
liver13.3
lung25.8
lymph node8.5
ovary76.8
pancreas9.8
placenta44.9
prostate34.8
salivary gland15.5
skin20.9
small intestine19.8
spleen10.6
stomach21
testis29.1
thyroid gland39.4
urinary bladder45.2
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowMedium
breastMedium
bronchusLow
cerebellumHigh
cerebral cortexHigh
colonLow
duodenumLow
endometrium 1High
endometrium 2High
epididymisLow
esophagusLow
fallopian tubeLow
gallbladderLow
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungHigh
lymph nodeMedium
nasopharynxLow
oral mucosaLow
ovaryHigh
pancreasMedium
placentaHigh
prostateLow
rectumLow
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineLow
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Low
stomach 2Low
testisLow
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612149, gene) Rna-binding motif protein 9; RBM9OMIM


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