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> Protein (NX_O43257)
Protein (NX_O43257)
Protein
Gene SymbolZNHIT1 to neXtProt (NX_O43257)
DescriptionZinc finger HIT domain-containing protein 1
Chromosome7
Location7q22.1 (100860949 ~ 100867471) to Ensembl
Sequene Features : Isoforms 1, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of G0 to G1 transition
.histone exchange
.regulation of T cell proliferation
  + 2 more...
.metal ion binding
.histone deacetylase binding
.nucleosome binding
.nucleus
.Swr1 complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 26 1
2014-09-19protein level
1 18 1
2014-05-27protein level
1 18 1
2014-02-25protein level
1 17 1
2013-12-09protein level
1 14 1
2013-11-01protein level
1 13 1
2013-09-12protein level
1 13 1
2013-08-17protein level
1 13 1
2013-07-15protein level
1 9 1
2013-06-11protein level
1 9 1
2013-02-12protein level
1 3 1
2012-12-20protein level
1 3 1
2012-10-30protein level
1 3 1
2012-10-07protein level
1 3 1
2012-08-24protein level
1 3 1
2012-07-28protein level
1 3 1
2012-06-08protein level
1 5 1
2012-05-07protein level
1 5 1
2012-04-10protein level
1 5 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43257-1
4 0 0 17524.7801
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347522,EBI-1199859 H2AFZ  
  .cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
.nucleosomal DNA binding
.chromatin DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding
  + 2 more...
.extracellular exosome
.nuclear heterochromatin
.nuclear euchromatin
  + 2 more...
2 EBI-347522,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
3 EBI-347522,EBI-396540 TP53BP1  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 5 more...
.telomeric DNA binding
.methylated histone binding
.damaged DNA binding
  + 3 more...
.cytoplasm
.replication fork
.nucleoplasm
  + 2 more...
4 EBI-347522,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
5 EBI-347522,EBI-298304 MAPK11  
  .stress-activated MAPK cascade
.positive regulation of muscle cell differentiation
.regulation of sequence-specific DNA binding transcription factor activity
  + 25 more...
.ATP binding
.MAP kinase activity
.protein serine/threonine kinase activity
.cytosol
.nucleoplasm
6 EBI-347522,EBI-73946 MAPK14  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of myoblast fusion
.regulation of cytokine production involved in inflammatory response
  + 64 more...
.NFAT protein binding
.ATP binding
.MAP kinase kinase activity
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 4 more...
7 EBI-347522,EBI-769329 ACTR6  
  .chromatin remodeling .N/A .cytoskeleton
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites100
bladder33
blood24
bone181
bone marrow20
brain36
cervix41
connective tissue53
embryonic tissue89
eye95
heart33
intestine129
kidney56
larynx42
liver121
lung65
lymph45
lymph node66
mammary gland66
mouth30
muscle84
nerve64
ovary147
pancreas126
parathyroid97
pharynx122
pituitary gland60
placenta77
prostate79
salivary gland98
skin156
spleen18
stomach62
testis25
thymus25
thyroid107
tonsil117
umbilical cord145
uterus60
vascular58
Health State
TissuesTPM*
normal51
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor107
cervical tumor28
chondrosarcoma72
colorectal tumor186
gastrointestinal tumor75
germ cell tumor60
glioma111
head and neck tumor104
kidney tumor87
leukemia21
liver tumor197
lung tumor77
lymphoma41
non-neoplasia62
ovarian tumor170
pancreatic tumor76
primitive neuroectodermal tumor of the CNS23
prostate cancer96
retinoblastoma107
skin tumor231
soft tissue/muscle tissue tumor63
uterine tumor88
Developmental Stage
TissuesTPM*
adult80
embryoid body71
blastocyst16
neonate64
fetus43
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.6
adrenal gland23.3
appendix19.1
bone marrow19.2
cerebral cortex17.9
colon30.3
duodenum28.8
esophagus16.6
gallbladder24.4
heart muscle23.5
kidney40.9
liver51.6
lung23.4
lymph node21.5
ovary16
pancreas14.4
placenta20.3
prostate22.9
salivary gland23.7
skin16.6
small intestine27
spleen28
stomach30.7
testis15.6
thyroid gland23.4
urinary bladder20.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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