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> Protein (NX_O43264)
Protein (NX_O43264)
Protein
Gene SymbolZW10 to neXtProt (NX_O43264)
DescriptionCentromere/kinetochore protein zw10 homolog
Chromosome11
Location11q23.2 (113603909 ~ 113644533) to Ensembl
Sequene Features : Isoforms 2, Variants 88, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.protein localization to kinetochore
.protein transport
  + 11 more...
.centromeric DNA binding .membrane
.cytosol
.kinetochore microtubule
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 88 6
2014-09-19protein level
1 68 6
2014-05-27protein level
1 68 6
2014-02-25protein level
1 68 6
2013-12-09protein level
1 45 6
2013-11-01protein level
1 45 6
2013-09-12protein level
1 45 6
2013-08-17protein level
1 45 6
2013-07-15protein level
1 32 5
2013-06-11protein level
1 32 5
2013-02-12protein level
1 14 4
2012-12-20protein level
1 14 4
2012-10-30protein level
1 19 4
2012-10-07protein level
1 19 4
2012-08-24protein level
1 16 4
2012-07-28protein level
1 16 4
2012-06-08protein level
1 16 4
2012-05-07protein level
1 16 4
2012-04-10protein level
1 16 4
2012-01-13protein level
1 7 4
2011-12-20protein level
1 7 4
2011-11-11protein level
1 7 3
2011-08-23protein level
1 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43264-1
6 33 0 88772.6162
NX_O43264-2
0 33 0 76757.5388
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1001217,EBI-1001132 ZWINT  
  .establishment of localization in cell
.cell division
.small GTPase mediated signal transduction
  + 3 more...
.protein N-terminus binding .dendrite
.cytosol
.cytoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
blood40
bone69
brain27
cervix41
connective tissue33
embryonic tissue46
eye4
intestine12
kidney14
liver14
lung5
lymph node22
mammary gland39
mouth90
muscle37
ovary29
pancreas32
placenta7
prostate73
spleen18
stomach10
testis62
thymus25
thyroid21
trachea38
uterus21
vascular58
Health State
TissuesTPM*
normal23
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma84
colorectal tumor17
gastrointestinal tumor25
germ cell tumor49
glioma37
head and neck tumor44
leukemia42
liver tumor31
lung tumor9
lymphoma55
non-neoplasia20
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer96
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult33
embryoid body71
blastocyst81
fetus23
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6
adrenal gland6.7
appendix8.6
bone marrow5.4
cerebral cortex5.3
colon8.2
duodenum6.3
esophagus9.7
gallbladder7.1
heart muscle4.6
kidney6.5
liver5.5
lung5.5
lymph node9.3
ovary7.1
pancreas3.9
placenta6.6
prostate6.9
salivary gland6.1
skin11.4
small intestine6.7
spleen6.3
stomach6.5
testis13.8
thyroid gland7.3
urinary bladder8.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603954, gene) Zeste-white 10, drosophila, homolog of; ZW10OMIM


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