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> Protein (NX_O43281)
Protein (NX_O43281)
Protein
Gene SymbolEFS to neXtProt (NX_O43281)
DescriptionEmbryonal Fyn-associated substrate
Chromosome14
Location14q11.2 (23825611 ~ 23834961) to Ensembl
Sequene Features : Isoforms 3, Variants 78, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular signal transduction
.cell adhesion
.protein domain specific binding .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 78 2
2014-09-19protein level
3 59 2
2014-05-27protein level
3 59 2
2014-02-25protein level
2 59 2
2013-12-09protein level
2 45 2
2013-11-01protein level
2 44 2
2013-09-12protein level
2 44 2
2013-08-17protein level
2 44 2
2013-07-15protein level
2 31 2
2013-06-11protein level
2 31 2
2013-02-12transcript level
2 25 2
2012-12-20transcript level
2 25 2
2012-10-30transcript level
2 24 2
2012-10-07transcript level
2 24 1
2012-08-24transcript level
2 20 1
2012-07-28transcript level
2 20 1
2012-06-08transcript level
2 20 1
2012-05-07transcript level
2 20 1
2012-04-10transcript level
2 20 1
2012-01-13transcript level
2 14 1
2011-12-20transcript level
2 14 1
2011-11-11transcript level
2 14 1
2011-08-23protein level
2 14 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43281-1
4 19 0 58778.5491
NX_O43281-2
0 20 0 48947.6522
NX_O43281-3
1 17 0 40930.6952
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-718488,EBI-1050769 NUP155  
  .regulation of cellular response to heat
.atrial cardiac muscle cell action potential
.transmembrane transport
  + 19 more...
.structural constituent of nuclear pore
.transporter activity
.nuclear membrane
.membrane
.nuclear pore
.nuclear envelope
2 EBI-718488,EBI-311323 SORBS2  
  .cell migration
.cell adhesion
.actin filament organization
.metal ion binding
.poly(A) RNA binding
.structural constituent of muscle
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.actin cytoskeleton
  + 2 more...
3 EBI-718488,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
4 EBI-718488,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
5 EBI-718488,EBI-1051152 OSTF1  
  .signal transduction
.ossification
.N/A .extracellular exosome
.cytoplasm
.intracellular
6 EBI-718488,EBI-6423734 TSSK1B  
  .intracellular signal transduction
.spermatid development
.multicellular organismal development
.protein phosphorylation
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.motile cilium
.cytoplasm
.nucleus
.acrosomal vesicle
7 EBI-718488,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
brain47
connective tissue60
ear186
embryonic tissue70
eye33
heart100
intestine8
kidney33
larynx42
lung26
mammary gland26
mouth30
muscle9
nerve128
ovary19
pancreas28
placenta70
prostate58
skin47
testis29
trachea38
umbilical cord72
uterus47
vascular19
Health State
TissuesTPM*
normal43
chondrosarcoma60
germ cell tumor30
glioma130
head and neck tumor22
kidney tumor14
lung tumor9
non-neoplasia51
primitive neuroectodermal tumor of the CNS7
prostate cancer38
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult33
embryoid body42
blastocyst146
neonate96
fetus70
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.4
adrenal gland9.6
appendix4.4
cerebral cortex16.9
colon3.4
duodenum2.2
esophagus18.6
gallbladder7.5
heart muscle3.6
kidney3.3
lung6.6
lymph node2.7
ovary22.7
placenta11.6
prostate20.2
salivary gland12.2
skin39
small intestine3.1
spleen4.9
stomach2.3
testis4.1
thyroid gland4.9
urinary bladder9.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609906, gene) Embryonal fyn-associated substrate; EFSOMIM


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