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> Protein (NX_O43291)
Protein (NX_O43291)
Protein
Gene SymbolSPINT2 to neXtProt (NX_O43291)
DescriptionKunitz-type protease inhibitor 2
Chromosome19
Location19q13.2 (38734675 ~ 38783254) to Ensembl
Sequene Features : Isoforms 2, Variants 35, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell motility
.negative regulation of cell-cell adhesion
.negative regulation of endopeptidase activity
.movement of cell or subcellular component
.serine-type endopeptidase inhibitor activity
.endopeptidase inhibitor activity
.integral component of membrane
.cytoplasm
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 35 16
2014-09-19protein level
2 27 16
2014-05-27protein level
2 27 16
2014-02-25protein level
2 27 16
2013-12-09protein level
2 19 16
2013-11-01protein level
2 18 15
2013-09-12protein level
2 18 15
2013-08-17protein level
2 18 15
2013-07-15protein level
2 9 9
2013-06-11protein level
2 9 9
2013-02-12protein level
2 7 12
2012-12-20protein level
2 7 12
2012-10-30protein level
2 7 12
2012-10-07protein level
2 7 8
2012-08-24protein level
2 7 8
2012-07-28protein level
2 7 8
2012-06-08protein level
2 11 8
2012-05-07protein level
2 11 8
2012-04-10protein level
1 11 8
2012-01-13protein level
1 13 8
2011-12-20protein level
1 13 8
2011-11-11protein level
1 13 8
2011-08-23protein level
1 13 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43291-1
3 9 0 28209.7376
NX_O43291-2
1 9 0 21813.7946
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites376
bladder100
blood163
bone13
bone marrow41
brain68
cervix103
connective tissue60
embryonic tissue385
esophagus99
eye134
heart111
intestine435
kidney128
larynx127
liver19
lung176
lymph45
lymph node278
mammary gland204
mouth60
nerve128
ovary1271
pancreas637
parathyroid534
pharynx49
pituitary gland302
placenta388
prostate316
salivary gland98
skin99
stomach585
testis126
thymus12
thyroid300
trachea19
uterus310
vascular19
Health State
TissuesTPM*
normal141
adrenal tumor79
bladder carcinoma511
breast (mammary gland) tumor225
cervical tumor115
chondrosarcoma48
colorectal tumor559
esophageal tumor115
gastrointestinal tumor514
germ cell tumor87
glioma83
head and neck tumor156
kidney tumor246
leukemia148
liver tumor20
lung tumor194
lymphoma96
non-neoplasia186
ovarian tumor1522
pancreatic tumor923
primitive neuroectodermal tumor of the CNS7
prostate cancer520
skin tumor55
uterine tumor721
Developmental Stage
TissuesTPM*
adult214
embryoid body400
blastocyst292
neonate32
fetus86
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.5
adrenal gland39.4
appendix62.3
bone marrow48
cerebral cortex37.7
colon262.6
duodenum194
esophagus160.8
gallbladder108.1
heart muscle10.7
kidney147.2
liver8.1
lung138.5
lymph node35.3
ovary74.9
pancreas87.6
placenta167
prostate184.7
salivary gland328.3
skin156.2
small intestine206.3
spleen46.4
stomach195.1
testis164.4
thyroid gland276.7
urinary bladder106.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#270420, phenotype) Diarrhea 3, secretory sodium, congenital; DIAR3OMIM
2(*605124, gene) Serine protease inhibitor, kunitz-type, 2; SPINT2OMIM


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