Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O43293)
Protein (NX_O43293)
Protein
Gene SymbolDAPK3 to neXtProt (NX_O43293)
DescriptionDeath-associated protein kinase 3
Chromosome19
Location19p13.3 (3958451 ~ 3971121) to Ensembl
Sequene Features : Isoforms 2, Variants 62, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 23 more...
.leucine zipper domain binding
.protein homodimerization activity
.identical protein binding
  + 5 more...
.membrane raft
.PML body
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 62 11
2014-09-19protein level
2 48 11
2014-05-27protein level
2 48 11
2014-02-25protein level
2 48 11
2013-12-09protein level
2 34 11
2013-11-01protein level
2 33 11
2013-09-12protein level
2 33 11
2013-08-17protein level
2 33 11
2013-07-15protein level
2 21 11
2013-06-11protein level
2 21 11
2013-02-12protein level
2 12 20
2012-12-20protein level
2 11 20
2012-10-30protein level
2 11 20
2012-10-07protein level
2 11 11
2012-08-24protein level
2 8 11
2012-07-28protein level
2 8 11
2012-06-08protein level
2 12 11
2012-05-07protein level
2 12 11
2012-04-10protein level
2 12 11
2012-01-13protein level
2 9 11
2011-12-20protein level
2 9 11
2011-11-11protein level
1 9 3
2011-08-23protein level
1 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43293-1
6 10 1 52503.2259
NX_O43293-2
1 10 1 37025.2969
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77293,EBI-351726 PPP1R12A  
  .centrosome organization
.regulation of nucleocytoplasmic transport
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.14-3-3 protein binding
.protein kinase binding
.phosphatase regulator activity
  + 2 more...
.PTW/PP1 phosphatase complex
.contractile fiber
.actin cytoskeleton
  + 6 more...
2 EBI-77293,EBI-3923210 TCP10L  
  .negative regulation of transcription from RNA polymerase II promoter .repressing transcription factor binding
.protein self-association
.identical protein binding
.RNA polymerase II transcription corepressor activity
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood16
bone27
brain38
cervix20
connective tissue20
embryonic tissue51
esophagus99
eye81
heart67
intestine51
kidney47
liver19
lung47
lymph node77
mammary gland59
mouth90
muscle9
ovary19
pancreas28
pharynx73
placenta52
prostate42
salivary gland49
skin66
spleen56
stomach52
testis62
thymus87
tonsil58
umbilical cord72
uterus25
vascular135
Health State
TissuesTPM*
normal46
breast (mammary gland) tumor21
chondrosarcoma12
colorectal tumor26
esophageal tumor115
gastrointestinal tumor33
germ cell tumor121
glioma83
head and neck tumor52
kidney tumor87
leukemia31
liver tumor31
lung tumor48
non-neoplasia51
pancreatic tumor19
primitive neuroectodermal tumor of the CNS62
prostate cancer9
skin tumor31
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult43
embryoid body85
blastocyst65
neonate64
fetus30
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.1
adrenal gland16.2
appendix25.7
bone marrow11.9
cerebral cortex34.8
colon24.7
duodenum25.2
esophagus26.4
gallbladder34.3
heart muscle61.5
kidney18.6
liver14.8
lung40.7
lymph node19.6
ovary23.4
pancreas16.9
placenta33
prostate43.7
salivary gland15.8
skin19.4
small intestine23.6
spleen28.3
stomach30.3
testis32.8
thyroid gland16.1
urinary bladder36.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603289, gene) Death-associated protein kinase 3; DAPK3OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center