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> Protein (NX_O43294)
Protein (NX_O43294)
Protein
Gene SymbolTGFB1I1 to neXtProt (NX_O43294)
DescriptionTransforming growth factor beta-1-induced transcript 1 protein
Chromosome16
Location16p11.2 (31482906 ~ 31489281) to Ensembl
Sequene Features : Isoforms 2, Variants 49, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription, DNA-templated
.negative regulation of fat cell differentiation
.cell fate commitment
  + 12 more...
.I-SMAD binding
.androgen receptor binding
.Roundabout binding
  + 2 more...
.nuclear matrix
.focal adhesion
.cytoskeleton
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 49 12
2014-09-19protein level
2 34 12
2014-05-27protein level
2 34 12
2014-02-25protein level
2 33 12
2013-12-09protein level
2 25 12
2013-11-01protein level
2 24 12
2013-09-12protein level
2 24 11
2013-08-17protein level
2 24 11
2013-07-15protein level
2 14 11
2013-06-11protein level
2 14 11
2013-02-12protein level
2 7 22
2012-12-20protein level
2 8 22
2012-10-30protein level
2 5 22
2012-10-07protein level
2 5 11
2012-08-24protein level
2 5 11
2012-07-28protein level
2 5 11
2012-06-08protein level
2 17 11
2012-05-07protein level
2 16 11
2012-04-10protein level
2 16 11
2012-01-13protein level
2 14 11
2011-12-20protein level
2 14 11
2011-11-11protein level
2 14 9
2011-08-23protein level
2 14 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43294-1
1 20 0 49781.6418
NX_O43294-2
0 20 0 47909.8009
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1051449,EBI-703044 ITGA4  
  .negative regulation of protein homodimerization activity
.T cell migration
.chorio-allantoic fusion
  + 18 more...
.cell adhesion molecule binding
.metal ion binding
.extracellular exosome
.integrin alpha4-beta7 complex
.membrane
  + 5 more...
2 EBI-1051449,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bone83
brain37
cervix41
connective tissue60
embryonic tissue56
esophagus248
eye62
heart33
intestine90
kidney28
liver19
lung38
mammary gland39
mouth15
muscle131
ovary167
pancreas14
placenta130
prostate47
skin52
spleen131
stomach104
testis27
thymus12
thyroid21
umbilical cord581
uterus258
vascular38
Health State
TissuesTPM*
normal66
breast (mammary gland) tumor21
chondrosarcoma48
colorectal tumor8
esophageal tumor173
gastrointestinal tumor33
germ cell tumor18
glioma102
head and neck tumor14
kidney tumor43
liver tumor20
lung tumor38
non-neoplasia82
ovarian tumor105
pancreatic tumor28
primitive neuroectodermal tumor of the CNS125
skin tumor15
soft tissue/muscle tissue tumor231
uterine tumor44
Developmental Stage
TissuesTPM*
adult60
embryoid body85
blastocyst16
neonate257
fetus34
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue40.2
adrenal gland18.4
appendix36.6
bone marrow1.2
cerebral cortex2.3
colon35.8
duodenum18.8
esophagus70.3
gallbladder43.7
heart muscle29.2
kidney11
liver4.5
lung35
lymph node12.4
ovary47.3
pancreas3.2
placenta33.9
prostate62.7
salivary gland16.4
skin8.5
small intestine22.7
spleen24.7
stomach13.6
testis12
thyroid gland13.5
urinary bladder71.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602353, gene) Transforming growth factor, beta-1-induced 1; TGFB1I1OMIM


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