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> Protein (NX_O43298)
Protein (NX_O43298)
Protein
Gene SymbolZBTB43 to neXtProt (NX_O43298)
DescriptionZinc finger and BTB domain-containing protein 43
Chromosome9
Location9q33.3 (129567285 ~ 129600489) to Ensembl
Sequene Features : Isoforms 1, Variants 42, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 42 1
2014-09-19protein level
1 23 1
2014-05-27protein level
1 23 1
2014-02-25protein level
1 23 1
2013-12-09protein level
1 18 1
2013-11-01protein level
1 17 1
2013-09-12protein level
1 17 0
2013-08-17protein level
1 17 0
2013-07-15protein level
1 11 0
2013-06-11protein level
1 11 0
2013-02-12protein level
1 7 1
2012-12-20protein level
1 7 1
2012-10-30protein level
1 8 1
2012-10-07protein level
1 8 1
2012-08-24protein level
1 7 1
2012-07-28protein level
1 7 1
2012-06-08protein level
1 7 1
2012-05-07protein level
1 4 1
2012-04-10protein level
1 4 1
2012-01-13protein level
1 4 1
2011-12-20protein level
1 4 1
2011-11-11protein level
1 4 1
2011-08-23protein level
1 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43298-1
23 0 0 52596.8307
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740718,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
2 EBI-740718,EBI-357622 PSMD3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 22 more...
.enzyme regulator activity .extracellular exosome
.proteasome accessory complex
.membrane
  + 6 more...
3 EBI-740718,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
4 EBI-740718,EBI-718116 ARR3  
  .visual perception
.signal transduction
.endocytosis
.regulation of protein phosphorylation
.N/A .synapse
.cytoplasm
.photoreceptor inner segment
.photoreceptor outer segment
5 EBI-740718,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
6 EBI-740718,EBI-10233719 DIP2A  
  .regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
7 EBI-740718,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
8 EBI-740718,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
9 EBI-740718,EBI-10246152 SYT6  
  .acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
10 EBI-740718,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
11 EBI-740718,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder66
blood57
bone27
brain20
cervix20
embryonic tissue18
esophagus99
eye33
heart11
intestine34
kidney37
liver63
lung68
lymph node66
mammary gland59
muscle37
nerve64
ovary59
pancreas4
parathyroid48
pharynx24
placenta24
prostate10
skin9
spleen18
stomach31
testis55
thymus37
thyroid42
uterus17
vascular58
Health State
TissuesTPM*
normal38
adrenal tumor79
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma24
colorectal tumor8
esophageal tumor115
gastrointestinal tumor25
germ cell tumor41
glioma18
head and neck tumor7
kidney tumor14
leukemia10
liver tumor20
non-neoplasia10
ovarian tumor39
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult29
embryoid body14
blastocyst16
fetus57
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.7
adrenal gland5
appendix5.2
bone marrow32.2
cerebral cortex6
colon4.2
duodenum4.7
esophagus8.5
gallbladder5.5
heart muscle7.5
kidney4.1
liver4.2
lung5.8
lymph node5.4
ovary6.1
pancreas2.5
placenta5.6
prostate8.2
salivary gland4.8
skin7.3
small intestine4.5
spleen4.8
stomach5.9
testis16.7
thyroid gland5.9
urinary bladder4.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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