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> Protein (NX_O43316)
Protein (NX_O43316)
Protein
Gene SymbolPAX4 to neXtProt (NX_O43316)
DescriptionPaired box protein Pax-4
Chromosome7
Location7q32.1 (127250346 ~ 127255982) to Ensembl
Sequene Features : Isoforms 3, Variants 91, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.retina development in camera-type eye
.response to cAMP
.positive regulation of cell differentiation
  + 6 more...
.double-stranded DNA binding
.DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 91 0
2014-09-19protein level
3 67 0
2014-05-27protein level
3 66 0
2014-02-25protein level
3 66 0
2013-12-09protein level
3 59 0
2013-11-01protein level
3 54 0
2013-09-12protein level
3 54 0
2013-08-17protein level
3 54 0
2013-07-15protein level
3 43 0
2013-06-11protein level
3 43 0
2013-02-12protein level
3 22 0
2012-12-20protein level
3 24 0
2012-10-30protein level
3 28 0
2012-10-07protein level
3 28 0
2012-08-24protein level
3 23 0
2012-07-28protein level
3 23 0
2012-06-08protein level
3 9 0
2012-05-07protein level
3 9 0
2012-04-10protein level
3 9 0
2012-01-13protein level
3 9 0
2011-12-20protein level
3 10 0
2011-11-11protein level
3 10 0
2011-08-23protein level
3 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43316-1
2 17 0 37808.398
NX_O43316-2
1 14 0 29801.4677
NX_O43316-4
2 16 0 37037.0911
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#125853, phenotype) Diabetes mellitus, noninsulin-dependent; NIDDMOMIM
2(*167413, gene) Paired box gene 4; PAX4OMIM
3(%222100, phenotype) Diabetes mellitus, insulin-dependent; IDDMOMIM
4(#612225, phenotype) Maturity-onset diabetes of the young, type 9; MODY9OMIM
5(#612227, phenotype) Diabetes mellitus, ketosis-prone; KPDOMIM


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