Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O43318)
Protein (NX_O43318)
Protein
Gene SymbolMAP3K7 to neXtProt (NX_O43318)
DescriptionMitogen-activated protein kinase kinase kinase 7
Chromosome6
Location6q15 (91223292 ~ 91296764) to Ensembl
Sequene Features : Isoforms 4, Variants 69, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 69 11
2014-09-19protein level
4 51 11
2014-05-27protein level
4 51 11
2014-02-25protein level
4 51 11
2013-12-09protein level
4 43 11
2013-11-01protein level
4 42 10
2013-09-12protein level
4 42 10
2013-08-17protein level
4 42 10
2013-07-15protein level
4 26 9
2013-06-11protein level
4 26 9
2013-02-12protein level
4 12 44
2012-12-20protein level
4 12 44
2012-10-30protein level
4 13 44
2012-10-07protein level
4 13 11
2012-08-24protein level
4 3 11
2012-07-28protein level
4 3 11
2012-06-08protein level
4 4 11
2012-05-07protein level
4 4 11
2012-04-10protein level
4 4 11
2012-01-13protein level
4 2 11
2011-12-20protein level
4 2 11
2011-11-11protein level
4 2 8
2011-08-23protein level
3 2 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O43318-1
0 27 0 67153.1296
NX_O43318-2
0 26 0 64188.5087
NX_O43318-3
0 23 0 56669.8421
NX_O43318-4
0 22 0 53705.2212
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-358684,EBI-359751 PPP6C  
  .protein dephosphorylation
.G1/S transition of mitotic cell cycle
.metal ion binding
.protein serine/threonine phosphatase activity
.cytosol
2 EBI-358684,EBI-492605 MAP2K7  
  .cellular response to sorbitol
.stress-activated MAPK cascade
.innate immune response
  + 22 more...
.protein phosphatase binding
.protein kinase binding
.enzyme binding
  + 6 more...
.cytosol
.cytoplasm
.nucleus
.intracellular
3 EBI-358700,EBI-296047 HSP90AA1  
  .regulation of cellular response to heat
.positive regulation of cardiac muscle contraction
.chaperone-mediated protein complex assembly
  + 26 more...
.GTPase binding
.poly(A) RNA binding
.protein homodimerization activity
  + 12 more...
.endocytic vesicle lumen
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
4 EBI-358684,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
5 EBI-358684,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
6 EBI-358700,EBI-358643 TAB1  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 24 more...
.kinase activator activity
.enzyme activator activity
.catalytic activity
.protein complex
.endosome membrane
.cytosol
  + 2 more...
7 EBI-358700,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
8 EBI-358684,EBI-359964 TAB3  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 19 more...
.zinc ion binding .extracellular exosome
.endosome membrane
.plasma membrane
  + 3 more...
9 EBI-358684,EBI-358708 TAB2  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 23 more...
.K63-linked polyubiquitin binding
.zinc ion binding
.endosome membrane
.plasma membrane
.cytosol
10 EBI-358684,EBI-366978 NLK  
  .protein autophosphorylation
.intracellular signal transduction
.serine phosphorylation of STAT3 protein
  + 8 more...
.SH2 domain binding
.ubiquitin protein ligase binding
.transcription factor binding
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
11 EBI-358684,EBI-78404 MAPK8IP1  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of JNK cascade
.negative regulation of JUN kinase activity
  + 3 more...
.kinesin binding
.MAP-kinase scaffold activity
.protein kinase inhibitor activity
.perinuclear region of cytoplasm
.synapse
.dentate gyrus mossy fiber
  + 8 more...
12 EBI-358684,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood40
bone41
bone marrow20
brain58
cervix20
connective tissue60
ear621
embryonic tissue46
eye28
heart44
intestine25
kidney85
liver14
lung53
lymph45
lymph node89
mammary gland66
mouth120
muscle56
nerve64
ovary59
pancreas37
placenta88
prostate31
skin37
spleen37
stomach62
testis57
thymus87
thyroid150
trachea38
uterus81
vascular135
Health State
TissuesTPM*
normal64
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma48
colorectal tumor26
gastrointestinal tumor33
germ cell tumor68
glioma37
head and neck tumor104
kidney tumor130
leukemia52
liver tumor31
lung tumor9
lymphoma69
non-neoplasia144
ovarian tumor78
primitive neuroectodermal tumor of the CNS23
prostate cancer38
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor77
Developmental Stage
TissuesTPM*
adult61
embryoid body42
blastocyst48
fetus89
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.1
adrenal gland14.3
appendix15.3
bone marrow9
cerebral cortex13.7
colon11.5
duodenum10.5
esophagus11.9
gallbladder16.2
heart muscle13.9
kidney10.1
liver6.8
lung11.3
lymph node20.5
ovary16.3
pancreas5.3
placenta15.8
prostate16
salivary gland10.3
skin16.7
small intestine10.5
spleen18.7
stomach11.3
testis13.3
thyroid gland17
urinary bladder16.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602614, gene) Mitogen-activated protein kinase kinase kinase 7; MAP3K7OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center